PMID- 23021330
OWN - NLM
STAT- MEDLINE
DCOM- 20130108
LR  - 20220311
IS  - 1558-3597 (Electronic)
IS  - 0735-1097 (Linking)
VI  - 60
IP  - 17
DP  - 2012 Oct 23
TI  - A diagnosis of the metabolic syndrome in youth that resolves by adult life is 
      associated with a normalization of high carotid intima-media thickness and type 2 
      diabetes mellitus risk: the Bogalusa heart and cardiovascular risk in young Finns 
      studies.
PG  - 1631-9
LID - S0735-1097(12)02948-8 [pii]
LID - 10.1016/j.jacc.2012.05.056 [doi]
AB  - OBJECTIVES: The aim of this study was to examine the effect of resolution from 
      metabolic syndrome (MetS) between youth and adulthood on carotid artery 
      intima-media thickness (IMT) and type 2 diabetes mellitus (T2DM). BACKGROUND: 
      Published findings demonstrate that youth with MetS are at increased risk of 
      cardio-metabolic outcomes in adulthood. It is not known whether this risk is 
      attenuated in those who resolve their MetS status. METHODS: Participants (n = 
      1,757) from 2 prospective cohort studies were examined as youth (when 9 to 18 
      years of age) and re-examined 14 to 27 years later. The presence of any 3 
      components (low high-density lipoprotein cholesterol, high triglycerides, high 
      glucose, high blood pressure, or high body mass index) previously shown to 
      predict adult outcomes defined youth MetS; the harmonized MetS criteria defined 
      adulthood MetS. Participants were classified according to their MetS status at 
      baseline and follow-up and examined for risk of high IMT and T2DM. RESULTS: Those 
      with MetS in youth and adulthood were at 3.4 times the risk (95% confidence 
      interval: 2.4 to 4.9) of high IMT and 12.2 times the risk (95% confidence 
      interval: 6.3 to 23.9) of T2DM in adulthood compared with those that did not have 
      MetS at either time-point, whereas those that had resolved their youth MetS 
      status by adulthood showed similar risk to those that did not have MetS at either 
      time-point (p > 0.20 for all comparisons). CONCLUSIONS: Although youth with MetS 
      are at increased risk of adult high IMT and T2DM, these data indicate that the 
      resolution of youth MetS by adulthood can go some way to normalize this risk to 
      levels seen in those who have never had MetS.
CI  - Copyright (c) 2012 American College of Cardiology Foundation. Published by Elsevier 
      Inc. All rights reserved.
FAU - Magnussen, Costan G
AU  - Magnussen CG
AD  - Research Centre of Applied and Preventive Cardiovascular Medicine, University of 
      Turku, Turku, Finland. cmagnuss@utas.edu.au
FAU - Koskinen, Juha
AU  - Koskinen J
FAU - Juonala, Markus
AU  - Juonala M
FAU - Chen, Wei
AU  - Chen W
FAU - Srinivasan, Sathanur R
AU  - Srinivasan SR
FAU - Sabin, Matthew A
AU  - Sabin MA
FAU - Thomson, Russell
AU  - Thomson R
FAU - Schmidt, Michael D
AU  - Schmidt MD
FAU - Nguyen, Quoc Manh
AU  - Nguyen QM
FAU - Xu, Ji-Hua
AU  - Xu JH
FAU - Skilton, Michael R
AU  - Skilton MR
FAU - Kahonen, Mika
AU  - Kahonen M
FAU - Laitinen, Tomi
AU  - Laitinen T
FAU - Taittonen, Leena
AU  - Taittonen L
FAU - Lehtimaki, Terho
AU  - Lehtimaki T
FAU - Ronnemaa, Tapani
AU  - Ronnemaa T
FAU - Viikari, Jorma S A
AU  - Viikari JS
FAU - Berenson, Gerald S
AU  - Berenson GS
FAU - Raitakari, Olli T
AU  - Raitakari OT
LA  - eng
GR  - R01 AG016592/AG/NIA NIH HHS/United States
GR  - HD-062783/HD/NICHD NIH HHS/United States
GR  - HD-061437/HD/NICHD NIH HHS/United States
GR  - AG-16592/AG/NIA NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20120926
PL  - United States
TA  - J Am Coll Cardiol
JT  - Journal of the American College of Cardiology
JID - 8301365
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - *Aging
MH  - Cardiovascular Diseases/diagnosis/*epidemiology/etiology
MH  - *Carotid Intima-Media Thickness
MH  - Child
MH  - Diabetes Mellitus, Type 2/*complications/diagnosis/epidemiology
MH  - Female
MH  - Finland/epidemiology
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Metabolic Syndrome/complications/*diagnosis/epidemiology
MH  - Prevalence
MH  - Prognosis
MH  - Remission, Spontaneous
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Time Factors
MH  - Young Adult
EDAT- 2012/10/02 06:00
MHDA- 2013/01/09 06:00
CRDT- 2012/10/02 06:00
PHST- 2011/11/16 00:00 [received]
PHST- 2012/04/16 00:00 [revised]
PHST- 2012/05/11 00:00 [accepted]
PHST- 2012/10/02 06:00 [entrez]
PHST- 2012/10/02 06:00 [pubmed]
PHST- 2013/01/09 06:00 [medline]
AID - S0735-1097(12)02948-8 [pii]
AID - 10.1016/j.jacc.2012.05.056 [doi]
PST - ppublish
SO  - J Am Coll Cardiol. 2012 Oct 23;60(17):1631-9. doi: 10.1016/j.jacc.2012.05.056. 
      Epub 2012 Sep 26.