PMID- 23021381
OWN - NLM
STAT- MEDLINE
DCOM- 20130509
LR  - 20121130
IS  - 1872-6844 (Electronic)
IS  - 0920-1211 (Linking)
VI  - 102
IP  - 3
DP  - 2012 Dec
TI  - Isolated febrile seizures are not associated with structural abnormalities of the 
      limbic system.
PG  - 216-20
LID - S0920-1211(12)00273-2 [pii]
LID - 10.1016/j.eplepsyres.2012.09.006 [doi]
AB  - The nature of the relationship between childhood febrile seizures (CFSs) and 
      temporal lobe epilepsy (TLE) remains unknown. The purpose of this study was to 
      perform a comprehensive analysis of measures of structural changes of the 
      hippocampus and limbic white matter to determine whether structural abnormalities 
      previously demonstrated in TLE were present in adults with isolated CFS. 
      Twenty-three adults with past CFS but no history of nonfebrile seizures and 21 
      controls underwent research MRI for measurement of volume, T2 and mean 
      diffusivity of the hippocampus and fractional anisotropy of the fornix and 
      cingulum. No significant group differences were found in any of the measured 
      parameters. These findings suggest that structural abnormalities of the 
      hippocampus and limbic white matter that have been demonstrated in TLE are not 
      associated with isolated CFS.
CI  - Copyright (c) 2012 Elsevier B.V. All rights reserved.
FAU - Gong, Gaolang
AU  - Gong G
AD  - State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal 
      University, Beijing, PR China.
FAU - Alexander, Ryan P D
AU  - Alexander RP
FAU - Shi, Feng
AU  - Shi F
FAU - Beaulieu, Christian
AU  - Beaulieu C
FAU - Gross, Donald W
AU  - Gross DW
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120926
PL  - Netherlands
TA  - Epilepsy Res
JT  - Epilepsy research
JID - 8703089
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Epilepsy, Temporal Lobe/*pathology
MH  - Female
MH  - Functional Laterality
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Limbic System/*pathology
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Seizures, Febrile/*pathology
MH  - Young Adult
EDAT- 2012/10/02 06:00
MHDA- 2013/05/10 06:00
CRDT- 2012/10/02 06:00
PHST- 2012/05/31 00:00 [received]
PHST- 2012/08/28 00:00 [revised]
PHST- 2012/09/09 00:00 [accepted]
PHST- 2012/10/02 06:00 [entrez]
PHST- 2012/10/02 06:00 [pubmed]
PHST- 2013/05/10 06:00 [medline]
AID - S0920-1211(12)00273-2 [pii]
AID - 10.1016/j.eplepsyres.2012.09.006 [doi]
PST - ppublish
SO  - Epilepsy Res. 2012 Dec;102(3):216-20. doi: 10.1016/j.eplepsyres.2012.09.006. Epub 
      2012 Sep 26.