PMID- 23021567
OWN - NLM
STAT- MEDLINE
DCOM- 20140501
LR  - 20220310
IS  - 1873-7862 (Electronic)
IS  - 0924-977X (Linking)
VI  - 23
IP  - 9
DP  - 2013 Sep
TI  - Brain-derived neurotrophic factor serum levels in cocaine-dependent patients 
      during early abstinence.
PG  - 1078-84
LID - S0924-977X(12)00249-0 [pii]
LID - 10.1016/j.euroneuro.2012.08.016 [doi]
AB  - Preclinical studies indicate that brain-derived neurotrophic factor (BDNF) is 
      involved in neuroplastic changes underlying enduring cocaine-seeking following 
      withdrawal. However, little is known about temporal changes in serum BDNF levels 
      or the involvement of BDNF in craving and abstinence in early-abstinent 
      cocaine-dependent patients. Twenty-three cocaine-dependent individuals (aged 
      33.65 +/- 6.85 years) completed a two-week detoxification program at an inpatient 
      facility. Two serum samples were collected for each patient at baseline and at 
      the end of the protocol. Serum samples were also collected for 46 healthy 
      controls (aged 35.52 +/- 9.37 years). Demographic, consumption and clinical data 
      were recorded for all patients. Significantly lower serum BDNF levels (p<.0001) 
      were observed for cocaine-dependent patients at baseline compared to healthy 
      controls. Serum BDNF levels increased significantly across 12 days of early 
      abstinence (p=.030). Baseline BDNF levels correlated with craving (p=.034). 
      Post-detoxification BDNF levels correlated with craving (p=.018), loss of control 
      (p<.000), abstinence measures (p=0.031), depression (p=0.036), and anxiety 
      (p=0.036). Post-detoxification BDNF levels also had predictive value for the loss 
      of control measure of craving. Chronic cocaine use is associated with decreased 
      serum BDNF. A progressive increase in serum BDNF levels during early abstinence 
      correlates with cocaine craving and abstinence symptoms and may reflect 
      increasing BDNF levels in different brain regions. These findings suggest that 
      serum BDNF may be a biomarker for cocaine addiction.
CI  - Copyright (c) 2012 Elsevier B.V. and ECNP. All rights reserved.
FAU - Corominas-Roso, Margarida
AU  - Corominas-Roso M
AD  - Department of Psychiatry, Vall d'Hebron University Hospital, CIBERSAM, Barcelona, 
      Universitat Autonoma de Barcelona, Catalonia, Spain. Electronic address: 
      mcoromin@vhebron.net.
FAU - Roncero, Carlos
AU  - Roncero C
FAU - Eiroa-Orosa, Francisco Jose
AU  - Eiroa-Orosa FJ
FAU - Gonzalvo, Begona
AU  - Gonzalvo B
FAU - Grau-Lopez, Lara
AU  - Grau-Lopez L
FAU - Ribases, Marta
AU  - Ribases M
FAU - Rodriguez-Cintas, Laia
AU  - Rodriguez-Cintas L
FAU - Sanchez-Mora, Cristina
AU  - Sanchez-Mora C
FAU - Ramos-Quiroga, Josep-Antoni
AU  - Ramos-Quiroga JA
FAU - Casas, Miguel
AU  - Casas M
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120926
PL  - Netherlands
TA  - Eur Neuropsychopharmacol
JT  - European neuropsychopharmacology : the journal of the European College of 
      Neuropsychopharmacology
JID - 9111390
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - Brain-Derived Neurotrophic Factor/biosynthesis/*blood
MH  - Cocaine-Related Disorders/*blood/*diagnosis
MH  - Cohort Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Substance Withdrawal Syndrome/*blood/*diagnosis
MH  - Time Factors
OTO - NOTNLM
OT  - Abstinence
OT  - Addiction
OT  - BDNF
OT  - Brain-derived neurotrophic factor
OT  - Cocaine
OT  - Craving
EDAT- 2012/10/02 06:00
MHDA- 2014/05/03 06:00
CRDT- 2012/10/02 06:00
PHST- 2012/03/11 00:00 [received]
PHST- 2012/08/24 00:00 [revised]
PHST- 2012/08/25 00:00 [accepted]
PHST- 2012/10/02 06:00 [entrez]
PHST- 2012/10/02 06:00 [pubmed]
PHST- 2014/05/03 06:00 [medline]
AID - S0924-977X(12)00249-0 [pii]
AID - 10.1016/j.euroneuro.2012.08.016 [doi]
PST - ppublish
SO  - Eur Neuropsychopharmacol. 2013 Sep;23(9):1078-84. doi: 
      10.1016/j.euroneuro.2012.08.016. Epub 2012 Sep 26.