PMID- 23021923
OWN - NLM
STAT- MEDLINE
DCOM- 20130605
LR  - 20121022
IS  - 2212-4411 (Electronic)
VI  - 114
IP  - 5
DP  - 2012 Nov
TI  - Mammary analog secretory carcinoma of salivary glands: a report of 2 cases in the 
      lips.
PG  - 630-5
LID - S2212-4403(12)01009-7 [pii]
LID - 10.1016/j.oooo.2012.07.480 [doi]
AB  - OBJECTIVE: This study presents 2 cases of labial mammary analog secretory 
      carcinoma (MASC) including diagnostic criteria and a review of literature. MASC 
      has not been previously described in the dental literature. DESIGN: Two cases of 
      MASC and 1 case of acinic cell carcinoma (ACC) of the lips were reviewed for 
      their microscopic and immunohistochemical features. Fluorescence in situ 
      hybridization (FISH) for the ETV6-NTRK3 translocation was performed. The clinical 
      features of 65 cases previously described in the medical literature are reviewed. 
      RESULTS: MASCs had hematoxylin and eosin features similar to those of ACC but 
      demonstrated larger, globular periodic acid-Schiff positive deposits, whereas ACC 
      had finer granular deposits. MASCs were strongly positive for S100, vimentin, and 
      mammaglobin, whereas ACC was negative for S100 and vimentin and only focally 
      mammaglobin positive. FISH demonstrated that MASCs were positive for ETV6 
      disruption. CONCLUSION: MASCs are newly described, can occur in a wide age range, 
      favor males, and can be misinterpreted as ACC or adenocarcinoma not otherwise 
      specified by routine microscopy.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Kratochvil, F James 3rd
AU  - Kratochvil FJ 3rd
AD  - Department of Pathology and Radiology, School of Dentistry, Oregon Health and 
      Science University, Portland, Oregon 97239-3001, USA. kratochv@ohsu.edu
FAU - Stewart, Jeffery C B
AU  - Stewart JC
FAU - Moore, Stephen R
AU  - Moore SR
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20120928
PL  - United States
TA  - Oral Surg Oral Med Oral Pathol Oral Radiol
JT  - Oral surgery, oral medicine, oral pathology and oral radiology
JID - 101576782
RN  - 0 (ETV6-NTRK3 fusion protein, human)
RN  - 0 (Oncogene Proteins, Fusion)
SB  - IM
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Lip Neoplasms/*diagnosis/genetics/pathology
MH  - Male
MH  - Middle Aged
MH  - Oncogene Proteins, Fusion/genetics
MH  - Salivary Gland Neoplasms/*diagnosis/genetics/pathology
EDAT- 2012/10/02 06:00
MHDA- 2013/06/06 06:00
CRDT- 2012/10/02 06:00
PHST- 2012/07/14 00:00 [received]
PHST- 2012/07/19 00:00 [revised]
PHST- 2012/07/24 00:00 [accepted]
PHST- 2012/10/02 06:00 [entrez]
PHST- 2012/10/02 06:00 [pubmed]
PHST- 2013/06/06 06:00 [medline]
AID - S2212-4403(12)01009-7 [pii]
AID - 10.1016/j.oooo.2012.07.480 [doi]
PST - ppublish
SO  - Oral Surg Oral Med Oral Pathol Oral Radiol. 2012 Nov;114(5):630-5. doi: 
      10.1016/j.oooo.2012.07.480. Epub 2012 Sep 28.