PMID- 23022015
OWN - NLM
STAT- MEDLINE
DCOM- 20130617
LR  - 20131121
IS  - 1873-6351 (Electronic)
IS  - 0278-6915 (Linking)
VI  - 51
DP  - 2013 Jan
TI  - Developmental effects of prenatal di-n-hexyl phthalate and dicyclohexyl phthalate 
      exposure on reproductive tract of male rats: Postnatal outcomes.
PG  - 123-36
LID - S0278-6915(12)00683-7 [pii]
LID - 10.1016/j.fct.2012.09.010 [doi]
AB  - The present study is to investigate the effects of in utero di-n-hexyl phthalate 
      (DHP) and dicyclohexyl phthalate exposure (DCHP) on the development of male 
      reproductive tract at prepubertal, pubertal and adult stages. Pregnant rats were 
      exposed to DHP and DCHP at doses of 0, 20, 100 and 500mg/kg/day, by gavage, on 
      gestational days (GD) 6-19. Testosterone (T) levels of prepubertal rats 
      diminished at high dose DHP and middle dose DCHP groups. MIS/AMH levels elevated 
      in DHP and DCHP groups. T levels of pubertal rats decreased in low and high dose 
      DHP and DCHP groups. Inhibin B levels of adult rats diminished in DCHP groups. 
      Atrophic and amorphous tubules, spermatogenic cell debris, apoptotic cells, 
      adherent tubules, Sertoli cell vacuolisation, prostatic atrophic tubules and 
      prostatic intraepithelial neoplasia (PIN) were observed in the reproductive 
      organs of treated animals at all developmental stages. There was an increase in 
      immunoexpression of MIS/AMH in testes of treated rats. There were no changes in 
      sperm head count but percentages of abnormal sperms increased. The diameters of 
      seminiferous and epididymal tubules in treatment groups were significantly lower. 
      This study shows that DHP and DCHP may have antiandrogenic effects on male 
      reproductive development before and after birth.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Aydogan Ahbab, Mufide
AU  - Aydogan Ahbab M
AD  - Department of Biology, Faculty of Science, University of Hacettepe, Ankara, 
      Turkey. mufideaydogan@gmail.com
FAU - Barlas, Nurhayat
AU  - Barlas N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120925
PL  - England
TA  - Food Chem Toxicol
JT  - Food and chemical toxicology : an international journal published for the British 
      Industrial Biological Research Association
JID - 8207483
RN  - 0 (Phthalic Acids)
RN  - 0 (Plasticizers)
RN  - 3XMK78S47O (Testosterone)
RN  - 42MAH1QFG5 (di-n-hexyl phthalate)
RN  - 80497-65-0 (Anti-Mullerian Hormone)
RN  - CGD15M7H2N (dicyclohexyl phthalate)
SB  - IM
MH  - Animals
MH  - Anti-Mullerian Hormone/blood
MH  - Epididymis/drug effects
MH  - Female
MH  - Male
MH  - Maternal Exposure
MH  - Organ Size/drug effects
MH  - Phthalic Acids/*toxicity
MH  - Plasticizers/*toxicity
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Prostate/drug effects/pathology
MH  - Puberty
MH  - Rats
MH  - Rats, Wistar
MH  - Sertoli Cells/drug effects/pathology
MH  - Sperm Count
MH  - Sperm Head/drug effects
MH  - Testis/*drug effects/pathology
MH  - Testosterone/blood
EDAT- 2012/10/02 06:00
MHDA- 2013/06/19 06:00
CRDT- 2012/10/02 06:00
PHST- 2012/06/21 00:00 [received]
PHST- 2012/09/10 00:00 [revised]
PHST- 2012/09/11 00:00 [accepted]
PHST- 2012/10/02 06:00 [entrez]
PHST- 2012/10/02 06:00 [pubmed]
PHST- 2013/06/19 06:00 [medline]
AID - S0278-6915(12)00683-7 [pii]
AID - 10.1016/j.fct.2012.09.010 [doi]
PST - ppublish
SO  - Food Chem Toxicol. 2013 Jan;51:123-36. doi: 10.1016/j.fct.2012.09.010. Epub 2012 
      Sep 25.