PMID- 23022197
OWN - NLM
STAT- MEDLINE
DCOM- 20130322
LR  - 20121026
IS  - 1090-2104 (Electronic)
IS  - 0006-291X (Linking)
VI  - 427
IP  - 3
DP  - 2012 Oct 26
TI  - BDNF, produced by a TPO-stimulated megakaryocytic cell line, regulates autocrine 
      proliferation.
PG  - 542-6
LID - S0006-291X(12)01840-2 [pii]
LID - 10.1016/j.bbrc.2012.09.093 [doi]
AB  - While human platelets release endogenous brain-derived neurotrophic factor (BDNF) 
      upon activation, a previous report on MEG-01, a megakaryocytic cell line, found 
      no trace of BDNF production, and the pathophysiological function of platelet BDNF 
      has remained elusive. In the present study, we demonstrate that MEG-01 produces 
      BDNF in the presence of TPO and that this serves to potentiate cell 
      proliferation. Our in vitro findings suggest that BDNF regulates MEG-01 
      proliferation in an autocrine manner, and we suggest that BDNF may be a 
      physiological autocrine regulator of megakaryocyte progenitors.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Tamura, Shogo
AU  - Tamura S
AD  - Graduate School of Health Sciences, Hokkaido University, Sapporo, Japan.
FAU - Nagasawa, Ayumi
AU  - Nagasawa A
FAU - Masuda, Yuya
AU  - Masuda Y
FAU - Tsunematsu, Tetsuya
AU  - Tsunematsu T
FAU - Hayasaka, Koji
AU  - Hayasaka K
FAU - Matsuno, Kazuhiko
AU  - Matsuno K
FAU - Shimizu, Chikara
AU  - Shimizu C
FAU - Ozaki, Yukio
AU  - Ozaki Y
FAU - Moriyama, Takanori
AU  - Moriyama T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120926
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 9014-42-0 (Thrombopoietin)
SB  - IM
MH  - Autocrine Communication/drug effects/*physiology
MH  - Brain-Derived Neurotrophic Factor/*biosynthesis
MH  - Cell Line
MH  - *Cell Proliferation
MH  - Humans
MH  - Megakaryocytes/*cytology/drug effects/metabolism
MH  - Thrombopoietin/pharmacology
EDAT- 2012/10/02 06:00
MHDA- 2013/03/23 06:00
CRDT- 2012/10/02 06:00
PHST- 2012/09/13 00:00 [received]
PHST- 2012/09/14 00:00 [accepted]
PHST- 2012/10/02 06:00 [entrez]
PHST- 2012/10/02 06:00 [pubmed]
PHST- 2013/03/23 06:00 [medline]
AID - S0006-291X(12)01840-2 [pii]
AID - 10.1016/j.bbrc.2012.09.093 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2012 Oct 26;427(3):542-6. doi: 
      10.1016/j.bbrc.2012.09.093. Epub 2012 Sep 26.