PMID- 23022574
OWN - NLM
STAT- MEDLINE
DCOM- 20130830
LR  - 20181203
IS  - 1879-1220 (Electronic)
IS  - 0960-0760 (Linking)
VI  - 136
DP  - 2013 Jul
TI  - The delicate balance between vitamin D, calcium and bone homeostasis: lessons 
      learned from intestinal- and osteocyte-specific VDR null mice.
PG  - 102-6
LID - S0960-0760(12)00185-9 [pii]
LID - 10.1016/j.jsbmb.2012.09.019 [doi]
AB  - The serum calcium levels and the calcium content of the skeleton are highly 
      interdependent. Indeed, bone requires calcium to preserve its strength, but it is 
      at the same time also the predominant calcium storage from which calcium can be 
      mobilized to supply the serum pool. The active form of vitamin D [1,25(OH)2D] 
      plays a crucial role in regulating the transfer of calcium between blood and 
      bone, evidenced by experimental data obtained from systemic, intestinal-specific 
      and osteocyte-specific vitamin D receptor (Vdr) null mice. In fact, 1,25(OH)2D is 
      required to maintain normocalcemia and bone health by enhancing intestinal 
      calcium absorption when dietary calcium intake is normal/low. When, however, 
      insufficient calcium is absorbed via the intestine, 1,25(OH)2D levels will 
      increase and will act on mature osteoblasts and osteocytes to minimize calcium 
      levels in bone tissue in favor of the blood calcium pool. Mechanistically, the 
      high 1,25(OH)2D levels enhance bone remodeling which leads to osteopenia, and 
      suppress bone matrix mineralization by increasing the levels of mineralization 
      inhibitors, which causes hyperosteoidosis and hypomineralization. Thus, depending 
      on the intestinal calcium acquisition, 1,25(OH)2D will target the intestine 
      and/or the skeleton to maintain calcium levels in serum within a normal range.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Lieben, Liesbet
AU  - Lieben L
AD  - Clinical and Experimental Endocrinology, KU Leuven, Leuven, Belgium.
FAU - Carmeliet, Geert
AU  - Carmeliet G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20120925
PL  - England
TA  - J Steroid Biochem Mol Biol
JT  - The Journal of steroid biochemistry and molecular biology
JID - 9015483
RN  - 0 (Receptors, Calcitriol)
RN  - 1406-16-2 (Vitamin D)
RN  - 66772-14-3 (1,25-dihydroxyvitamin D)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Animals
MH  - Bone Resorption/genetics/metabolism
MH  - Bone and Bones/metabolism
MH  - Calcification, Physiologic/genetics
MH  - Calcium/blood/*metabolism
MH  - Homeostasis/genetics
MH  - Intestinal Mucosa/metabolism
MH  - Mice
MH  - Mice, Knockout
MH  - Receptors, Calcitriol/deficiency/genetics
MH  - Vitamin D/*analogs & derivatives/metabolism
EDAT- 2012/10/02 06:00
MHDA- 2013/08/31 06:00
CRDT- 2012/10/02 06:00
PHST- 2012/07/06 00:00 [received]
PHST- 2012/09/14 00:00 [revised]
PHST- 2012/09/17 00:00 [accepted]
PHST- 2012/10/02 06:00 [entrez]
PHST- 2012/10/02 06:00 [pubmed]
PHST- 2013/08/31 06:00 [medline]
AID - S0960-0760(12)00185-9 [pii]
AID - 10.1016/j.jsbmb.2012.09.019 [doi]
PST - ppublish
SO  - J Steroid Biochem Mol Biol. 2013 Jul;136:102-6. doi: 10.1016/j.jsbmb.2012.09.019. 
      Epub 2012 Sep 25.