PMID- 23022914
OWN - NLM
STAT- MEDLINE
DCOM- 20130430
LR  - 20211021
IS  - 1872-9738 (Electronic)
IS  - 0892-0362 (Print)
IS  - 0892-0362 (Linking)
VI  - 34
IP  - 6
DP  - 2012 Nov-Dec
TI  - Maternal transfer of BDE-47 to offspring and neurobehavioral development in 
      C57BL/6J mice.
PG  - 571-80
LID - S0892-0362(12)00164-X [pii]
LID - 10.1016/j.ntt.2012.09.005 [doi]
AB  - Polybrominated diphenyl ethers (PBDEs) are flame retardants used worldwide in a 
      variety of commercial goods, and are now widely found in both environmental and 
      biological samples. BDE-47 is one of the most pervasive of these PBDE congeners 
      and therefore is of particular concern. In this study C57BL/6J mice were exposed 
      perinatally to 0.03, 0.1 or 1mg/kg/day of BDE-47, a dose range chosen to 
      encompass human exposure levels. Tissue levels of BDE-47 were measured in the 
      blood, brain, fat and milk of dams and in whole fetal homogenate and blood and 
      brain of pups on gestational day (GD) 15, and postnatal days (PNDs) 1, 10 and 21. 
      From GD 15 to PND 1 levels of BDE-47 increased within dam tissues and then 
      decreased from PNDs 1 to 21. Over the period of lactation levels in dam milk were 
      comparatively high when compared to both brain and blood for all dose groups. 
      Measurable levels of BDE-47 were found in the fetus on GD 15 confirming 
      gestational exposure. From PNDs 1 to 21, levels of BDE-47 in pup tissue increased 
      over the period of lactation due to the transfer of BDE-47 through milk. 
      Behavioral tests of fine motor function and learning and memory were carried out 
      between postnatal weeks 5-17 in order to evaluate the neurobehavioral toxicity of 
      BDE-47. Behavioral deficits were only seen in the Barnes spatial maze where mice 
      in the three exposure groups had longer latencies and traveled longer distances 
      to find the escape hole when compared to vehicle control mice. These results 
      support the conclusions that perinatal exposure to BDE-47 can have 
      neurodevelopmental consequences, and that lactational exposure represents a 
      significant exposure risk during development.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Koenig, Claire M
AU  - Koenig CM
AD  - Center for Children's Environmental Health, University of California Davis, 
      Davis, CA 95616, USA. cmkoenig@ucdavis.edu
FAU - Lango, Jozsef
AU  - Lango J
FAU - Pessah, Isaac N
AU  - Pessah IN
FAU - Berman, Robert F
AU  - Berman RF
LA  - eng
GR  - P01 ES011269/ES/NIEHS NIH HHS/United States
GR  - 5P42 ES04699/ES/NIEHS NIH HHS/United States
GR  - T32 ES007059/ES/NIEHS NIH HHS/United States
GR  - P42 ES004699/ES/NIEHS NIH HHS/United States
GR  - 1P01 ES11269/ES/NIEHS NIH HHS/United States
GR  - R01 ES014901/ES/NIEHS NIH HHS/United States
GR  - T32ES0007059/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20120928
PL  - United States
TA  - Neurotoxicol Teratol
JT  - Neurotoxicology and teratology
JID - 8709538
RN  - 0 (Environmental Pollutants)
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - 0 (Polybrominated Biphenyls)
RN  - 0N97R5X10X (2,2',4,4'-tetrabromodiphenyl ether)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/*drug effects
MH  - Environmental Pollutants/pharmacokinetics/*toxicity
MH  - Female
MH  - Halogenated Diphenyl Ethers
MH  - Male
MH  - *Maternal-Fetal Exchange
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Milk/metabolism
MH  - Motor Activity/drug effects
MH  - Nervous System/*drug effects/embryology/growth & development
MH  - Polybrominated Biphenyls/pharmacokinetics/*toxicity
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/*chemically induced/metabolism
MH  - Tissue Distribution
PMC - PMC3501584
MID - NIHMS410999
COIS- Conflict of interest statement The authors declare that there are no conflicts of 
      interest.
EDAT- 2012/10/02 06:00
MHDA- 2013/05/01 06:00
PMCR- 2013/11/01
CRDT- 2012/10/02 06:00
PHST- 2012/06/13 00:00 [received]
PHST- 2012/09/07 00:00 [revised]
PHST- 2012/09/21 00:00 [accepted]
PHST- 2012/10/02 06:00 [entrez]
PHST- 2012/10/02 06:00 [pubmed]
PHST- 2013/05/01 06:00 [medline]
PHST- 2013/11/01 00:00 [pmc-release]
AID - S0892-0362(12)00164-X [pii]
AID - 10.1016/j.ntt.2012.09.005 [doi]
PST - ppublish
SO  - Neurotoxicol Teratol. 2012 Nov-Dec;34(6):571-80. doi: 10.1016/j.ntt.2012.09.005. 
      Epub 2012 Sep 28.