PMID- 23023098
OWN - NLM
STAT- MEDLINE
DCOM- 20130326
LR  - 20221207
IS  - 1878-4216 (Electronic)
IS  - 0278-5846 (Linking)
VI  - 40
DP  - 2013 Jan 10
TI  - Brain-derived neurotrophic factor Val66Met polymorphism and alcohol-related 
      phenotypes.
PG  - 193-8
LID - S0278-5846(12)00243-6 [pii]
LID - 10.1016/j.pnpbp.2012.09.005 [doi]
AB  - Alcoholism is a chronic psychiatric disorder affecting neural pathways that 
      regulate motivation, stress, reward and arousal. Brain-derived neurotrophic 
      factor (BDNF) regulates mood, response to stress and interacts with 
      neurotransmitters and stress systems involved in reward pathways and addiction. 
      Aim of the study was to evaluate the association between a single nucleotide 
      polymorphism (BDNF Val66Met or rs6265) and alcohol related phenotypes in 
      Caucasian patients. In ethnically homogenous Caucasian subjects of the Croatian 
      origin, the BDNF Val66Met genotype distribution was determined in 549 male and 
      126 female patients with alcohol dependence and in 655 male and 259 female 
      healthy non-alcoholic control subjects. Based on the structured clinical 
      interview, additional detailed clinical interview, the Brown-Goodwin Scale, the 
      Hamilton Rating Scale for Depression and the Clinical Global Impression scores, 
      alcoholic patients were subdivided into those with or without comorbid 
      depression, aggression, delirium tremens, withdrawal syndrome, early/late onset 
      of alcohol abuse, prior suicidal attempt during lifetime, current suicidal 
      behavior, and severity of alcohol dependence. The results showed no significant 
      association between BDNF Val66Met variants and alcohol dependence and/or any of 
      the alcohol related phenotypes in either Caucasian women, or men, with alcohol 
      dependence. There are few limitations of the study. The overall study sample size 
      was large (N=1589) but not well-powered to detect differences in BDNF Val66Met 
      genotype distribution between studied groups. Healthy control women were older 
      than female alcoholic patients. Only one BDNF polymorphism (rs6265) was studied. 
      In conclusion, these data do not support the view that BDNF Val66Met polymorphism 
      correlates with the specific alcohol related phenotypes in ethnically homogenous 
      medication-free Caucasian subjects with alcohol dependence.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Nedic, Gordana
AU  - Nedic G
AD  - Division of Molecular Medicine, Rudjer Boskovic Institute, Bijenicka 54, HR-10000 
      Zagreb, Croatia.
FAU - Perkovic, Matea Nikolac
AU  - Perkovic MN
FAU - Sviglin, Korona Nenadic
AU  - Sviglin KN
FAU - Muck-Seler, Dorotea
AU  - Muck-Seler D
FAU - Borovecki, Fran
AU  - Borovecki F
FAU - Pivac, Nela
AU  - Pivac N
LA  - eng
GR  - K-1206/PUK_/Parkinson's UK/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120927
PL  - England
TA  - Prog Neuropsychopharmacol Biol Psychiatry
JT  - Progress in neuro-psychopharmacology & biological psychiatry
JID - 8211617
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Alcoholism/*genetics
MH  - Alleles
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Croatia
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
MH  - White People
EDAT- 2012/10/02 06:00
MHDA- 2013/03/27 06:00
CRDT- 2012/10/02 06:00
PHST- 2012/05/31 00:00 [received]
PHST- 2012/08/21 00:00 [revised]
PHST- 2012/09/14 00:00 [accepted]
PHST- 2012/10/02 06:00 [entrez]
PHST- 2012/10/02 06:00 [pubmed]
PHST- 2013/03/27 06:00 [medline]
AID - S0278-5846(12)00243-6 [pii]
AID - 10.1016/j.pnpbp.2012.09.005 [doi]
PST - ppublish
SO  - Prog Neuropsychopharmacol Biol Psychiatry. 2013 Jan 10;40:193-8. doi: 
      10.1016/j.pnpbp.2012.09.005. Epub 2012 Sep 27.