PMID- 23023380
OWN - NLM
STAT- MEDLINE
DCOM- 20140722
LR  - 20121001
IS  - 1735-367X (Electronic)
IS  - 1735-1383 (Linking)
VI  - 9
IP  - 3
DP  - 2012 Sep
TI  - Toll like receptor-4 896A/G gene variation, a risk factor for migraine headaches.
PG  - 159-67
AB  - BACKGROUND: The pathogenesis of migraine involves immune-mediated mechanisms in 
      the vascular endothelium. Toll like receptor 4 (TLR-4) is a signaling receptor of 
      innate immunity which plays a role in various neuropathologies related to neuron 
      inflammation. OBJECTIVE: This case/control study is aimed to investigate whether 
      TLR-4 896A/G variation is related to migraine headaches in an Iranian population. 
      METHODS: A total of 170 migraine patients (130 females, mean age 33.24 +/- 11 
      years) and 170 age, sex, and ethnicity matched healthy controls (118 females, 
      mean age of 31 +/- 10 years) were recruited. Genotyping was carried out using the 
      tetra primer amplification refractory mutation system (ARMS)-PCR. RESULTS: The 
      frequency of G allele was higher in migraine patients than the controls (15% vs. 
      4.7%; p<0.0001). Interestingly, the distribution of heterozygous 896A/G genotype 
      statistically differed between migraineurs and controls (25.3% vs. 8.2%, 
      p=0.00002, OR 3.87, 95% CI; 2.02-7.4). Multivariate logistic regression analysis 
      indicated that G allele in affected female migraineurs is an independent factor 
      associated with increased risk of migraine (OR 3.2, 95% CI 1.23-8.24, p=0.01). 
      CONCLUSION: Our results showed TLR-4 polymorphism as a genetic risk factor for 
      migraine. However, further studies in different populations are required to 
      elucidate the precise role of TLR-4 896A/G mutation in susceptibility to 
      migraine.
FAU - Rafiei, Alireza
AU  - Rafiei A
AD  - Neurology Ward, Department of Internal Medicine, Buali Hospital, Sari, Iran, 
      e-mail: abedinm20@gmail.com.
FAU - Abedini, Mahmoud
AU  - Abedini M
FAU - Hosseini, Seyed Hamzeh
AU  - Hosseini SH
FAU - Hosseini-Khah, Zahra
AU  - Hosseini-Khah Z
FAU - Bazrafshan, Behrouz
AU  - Bazrafshan B
FAU - Tehrani, Mohsen
AU  - Tehrani M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Iran
TA  - Iran J Immunol
JT  - Iranian journal of immunology : IJI
JID - 101282932
RN  - 0 (Inflammation Mediators)
RN  - 0 (Toll-Like Receptor 4)
SB  - IM
MH  - Adult
MH  - Female
MH  - Gene Frequency
MH  - Gene-Environment Interaction
MH  - Genetic Association Studies
MH  - *Genetic Predisposition to Disease
MH  - Humans
MH  - Immunity, Innate
MH  - Inflammation Mediators/metabolism
MH  - Iran
MH  - Male
MH  - Migraine Disorders/*genetics/immunology
MH  - Neurogenic Inflammation/genetics
MH  - Polymorphism, Single Nucleotide
MH  - Risk Factors
MH  - Sex Factors
MH  - Toll-Like Receptor 4/*genetics
MH  - Trigeminal Nerve/*immunology
MH  - Young Adult
EDAT- 2012/10/02 06:00
MHDA- 2014/07/23 06:00
CRDT- 2012/10/02 06:00
PHST- 2012/10/02 06:00 [entrez]
PHST- 2012/10/02 06:00 [pubmed]
PHST- 2014/07/23 06:00 [medline]
AID - 02 [pii]
PST - ppublish
SO  - Iran J Immunol. 2012 Sep;9(3):159-67.