PMID- 23023943
OWN - NLM
STAT- MEDLINE
DCOM- 20130617
LR  - 20130326
IS  - 1531-4995 (Electronic)
IS  - 0023-852X (Linking)
VI  - 123
IP  - 4
DP  - 2013 Apr
TI  - Gastroesophageal reflux evaluation in patients affected by chronic cough: Restech 
      versus multichannel intraluminal impedance/pH metry.
PG  - 980-4
LID - 10.1002/lary.23738 [doi]
AB  - OBJECTIVES/HYPOTHESIS: Oropharyngeal (OP) pH monitoring has been developed to 
      detect supra-esophageal gastric reflux (SEGR). The results obtained with OP 
      pH-metry and multichannel intraluminal impedance/pH monitoring (MII/pH) were 
      compared. STUDY DESIGN: Diagnostic study. METHODS: Ten patients (age 46.33 +/- 9.86 
      years) presenting with chronic coughing underwent simultaneous OP and MII/pH 
      recording. A 2-minute interval was allowed between events detected with both 
      techniques to be considered simultaneous. RESULTS: A total of 515 reflux episodes 
      were recorded with MII/pH (acid: 181; weakly acid: 310; weakly alkaline: 24); 180 
      (35%) reached the highest impedance channel (hypo-pharynx); 74/180 (41%) were not 
      related to a change in pH, according to the antimony electrode of the MII/pH 
      catheter located at the upper esophageal sphincter. The OP monitoring measured 39 
      acid events; 17 (43.6%) were swallows according to MII, and 15 (38.5%) were not 
      associated with MII or pH change. Only seven episodes were detected 
      simultaneously with both techniques (1.3% for MII vs. 18% for OP; P = 0.0002). We 
      found 49 pH-only refluxes at the pH sensor in the hypo-pharynx with MII/pH; only 
      three (6.1%) correlated with OP reflux. Correlation in time between cough and 
      reflux events was positive in 5/10 patients for MII (symptom index 5/10, symptom 
      association probability 4/10), but in 0/10 patients according to OP pH metry. 
      CONCLUSION: OP pH metry detected less reflux episodes than MII/pH; 35% of the OP 
      events were swallows according to impedance. Time correlation between cough and 
      reflux could not be demonstrated with OP pH metry.
CI  - Copyright (c) 2012 The American Laryngological, Rhinological, and Otological 
      Society, Inc.
FAU - Ummarino, Dario
AU  - Ummarino D
AD  - Department of Pediatrics, UZ Brussel, Brussels, Belgium.
FAU - Vandermeulen, Liv
AU  - Vandermeulen L
FAU - Roosens, Bart
AU  - Roosens B
FAU - Urbain, Daniel
AU  - Urbain D
FAU - Hauser, Bruno
AU  - Hauser B
FAU - Vandenplas, Yvan
AU  - Vandenplas Y
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20120928
PL  - United States
TA  - Laryngoscope
JT  - The Laryngoscope
JID - 8607378
SB  - IM
MH  - Adult
MH  - Aged
MH  - Chronic Disease
MH  - Cough/*complications
MH  - Electric Impedance
MH  - Esophageal pH Monitoring/*instrumentation
MH  - Gastroesophageal Reflux/complications/*diagnosis
MH  - Humans
MH  - Hydrogen-Ion Concentration
MH  - Middle Aged
EDAT- 2012/10/02 06:00
MHDA- 2013/06/19 06:00
CRDT- 2012/10/02 06:00
PHST- 2012/04/12 00:00 [received]
PHST- 2012/08/03 00:00 [revised]
PHST- 2012/08/22 00:00 [accepted]
PHST- 2012/10/02 06:00 [entrez]
PHST- 2012/10/02 06:00 [pubmed]
PHST- 2013/06/19 06:00 [medline]
AID - 10.1002/lary.23738 [doi]
PST - ppublish
SO  - Laryngoscope. 2013 Apr;123(4):980-4. doi: 10.1002/lary.23738. Epub 2012 Sep 28.