PMID- 23024033
OWN - NLM
STAT- MEDLINE
DCOM- 20130507
LR  - 20220330
IS  - 1097-0215 (Electronic)
IS  - 0020-7136 (Linking)
VI  - 132
IP  - 9
DP  - 2013 May 1
TI  - Type 2 diabetes mellitus, insulin-use and risk of bladder cancer in a large 
      cohort study.
PG  - 2186-91
LID - 10.1002/ijc.27878 [doi]
AB  - Type 2 diabetes mellitus (T2DM) is associated with increased bladder cancer 
      incidence in some, but not all, studies. Many studies had limited statistical 
      power and few examined risk by insulin-use, duration of diabetes or cancer stage. 
      We examined the association between T2DM and bladder cancer incidence in the 
      Cancer Prevention Study II Nutrition Cohort, a large prospective study with 
      information on insulin-use and duration of diabetes. Diabetes and insulin-use 
      were ascertained from a questionnaire at study enrollment in 1992 or 1993 and 
      updated in 1997 and every 2 years thereafter. During follow-up through 2007, 
      1,852 cases of incident bladder cancer were identified among 172,791 
      participants. Multivariable adjusted relative risks (RRs) and 95% confidence 
      intervals (CIs) were estimated using extended Cox regression modeling. There were 
      no associations of T2DM with the risk of bladder cancer overall (RR = 1.01, 95% 
      CI: 0.87-1.17), noninvasive disease (RR = 0.93, 95% CI: 0.76-1.14) or invasive 
      disease (RR = 1.13, 95% CI: 0.91-1.40). Compared to participants without T2DM, 
      risk of invasive bladder cancer was higher among participants who had had T2DM 
      for >15 years (RR = 1.63, 95% CI: 1.09-2.43) and among those using insulin (RR = 
      1.64, 95% CI: 1.18-2.27). These results do not support an association of T2DM 
      with overall bladder cancer incidence, but do suggest positive associations of 
      long-term T2DM and insulin-use or other factors correlated with severe diabetes, 
      with invasive bladder cancer incidence.
CI  - Copyright (c) 2012 UICC.
FAU - Newton, Christina C
AU  - Newton CC
AD  - Epidemiology Research Program, American Cancer Society, Atlanta, GA 30303-1002, 
      USA. christina.newton@cancer.org
FAU - Gapstur, Susan M
AU  - Gapstur SM
FAU - Campbell, Peter T
AU  - Campbell PT
FAU - Jacobs, Eric J
AU  - Jacobs EJ
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20121020
PL  - United States
TA  - Int J Cancer
JT  - International journal of cancer
JID - 0042124
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Insulin)
SB  - IM
MH  - Aged
MH  - Diabetes Complications/epidemiology/*etiology
MH  - Diabetes Mellitus, Type 2/*complications/drug therapy
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Hypoglycemic Agents/*therapeutic use
MH  - Insulin/*therapeutic use
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Prospective Studies
MH  - Risk Factors
MH  - Surveys and Questionnaires
MH  - Urinary Bladder Neoplasms/epidemiology/*etiology
EDAT- 2012/10/02 06:00
MHDA- 2013/05/08 06:00
CRDT- 2012/10/02 06:00
PHST- 2012/07/31 00:00 [received]
PHST- 2012/09/20 00:00 [accepted]
PHST- 2012/10/02 06:00 [entrez]
PHST- 2012/10/02 06:00 [pubmed]
PHST- 2013/05/08 06:00 [medline]
AID - 10.1002/ijc.27878 [doi]
PST - ppublish
SO  - Int J Cancer. 2013 May 1;132(9):2186-91. doi: 10.1002/ijc.27878. Epub 2012 Oct 
      20.