PMID- 23025952
OWN - NLM
STAT- MEDLINE
DCOM- 20121203
LR  - 20161125
IS  - 1555-9823 (Electronic)
IS  - 0003-1348 (Linking)
VI  - 78
IP  - 10
DP  - 2012 Oct
TI  - Fluorodeoxyglucose positron emission tomography-computed tomography: a novel 
      approach for the diagnosis of cholecystitis for equivocal diagnoses after 
      ultrasound imaging.
PG  - 1109-13
AB  - Although hepatobiliary iminodiacetic acid (HIDA) scan is often used when the 
      diagnosis of cholecystitis remains questionable after ultrasound, it carries a 
      high false-positive rate and has other limitations. Fluorodeoxyglucose positron 
      emission tomography-computed tomography (18FDG PET-CT) has recently gained 
      enthusiasm for its ability to detect infection and inflammation. In this study, 
      we evaluate the accuracy of 18FDG PET-CT in diagnosing cholecystitis. Nineteen 
      patients with suspected cholecystitis (Group S) underwent PET-CT and 10 had 
      positive PET-CT findings. Of these 10, nine underwent cholecystectomies, and 
      pathology confirmed cholecystitis in all nine. One patient was managed 
      nonoperatively as a result of multiple comorbidities. Of the nine patients with 
      negative PET-CT, six were managed nonoperatively, safely discharged, and had no 
      readmissions at 3-month follow-up. The other three patients with negative PET-CT 
      underwent cholecystectomies, and two showed no cholecystitis on pathology. The 
      third had mild to moderate cholecystitis with focal mucosal erosion/ulceration 
      without gallbladder wall thickening on pathology. 18FDG PET-CT detected 
      gallbladder inflammation in all but one patient with pathology-proven 
      cholecystitis with a sensitivity and specificity of 0.90 and 1.00, respectively. 
      18FDG-PET-CT appears to be a promising, rapid, direct, and accurate test in 
      diagnosing cholecystitis and could replace HIDA scan in cases that remain 
      equivocal after ultrasound.
FAU - Nasseri, Yosef
AU  - Nasseri Y
AD  - Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, California 
      90048, USA.
FAU - Ourian, Ariel J
AU  - Ourian AJ
FAU - Waxman, Alan
AU  - Waxman A
FAU - D'Angolo, Alessandro
AU  - D'Angolo A
FAU - Thomson, Louise E
AU  - Thomson LE
FAU - Margulies, Daniel R
AU  - Margulies DR
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am Surg
JT  - The American surgeon
JID - 0370522
RN  - 0 (Radiopharmaceuticals)
RN  - 0Z5B2CJX4D (Fluorodeoxyglucose F18)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Cholecystitis/*diagnostic imaging
MH  - Female
MH  - *Fluorodeoxyglucose F18
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Multimodal Imaging
MH  - *Positron-Emission Tomography
MH  - Prospective Studies
MH  - *Radiopharmaceuticals
MH  - Reproducibility of Results
MH  - *Tomography, X-Ray Computed
MH  - Ultrasonography
MH  - Young Adult
EDAT- 2012/10/03 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/10/03 06:00
PHST- 2012/10/03 06:00 [entrez]
PHST- 2012/10/03 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
PST - ppublish
SO  - Am Surg. 2012 Oct;78(10):1109-13.