PMID- 23026308
OWN - NLM
STAT- MEDLINE
DCOM- 20130328
LR  - 20211203
IS  - 1872-7573 (Electronic)
IS  - 0378-8741 (Linking)
VI  - 144
IP  - 2
DP  - 2012 Nov 21
TI  - Herb-drug pharmacokinetic interaction between radix astragali and pioglitazone in 
      rats.
PG  - 300-4
LID - S0378-8741(12)00607-1 [pii]
LID - 10.1016/j.jep.2012.09.012 [doi]
AB  - ETHNOPHARMACOLOGICAL RELEVANCE: Radix astragali (RA) was the most frequently used 
      traditional Chinese medicine (TCM) according to the statistics on 52 
      anti-diabetic formulas recorded in New National Traditional Chinese Medicine; it 
      was employed in 34 out of the 52 formulas. The aim of this study was to elucidate 
      potential pharmacokinetic interaction between RA and pioglitazone, and to provide 
      guidance for clinical medicine safety. MATERIALS AND METHODS: A specific and 
      rapid UPLC-MS/MS method was established to quantify pioglitazone in rat plasma. 
      Then healthy and type 2 diabetes mellitus (T2DM) rats were each divided into 
      control and RA decoction (RAD) administration groups-healthy, healthy-RAD, T2DM, 
      T2DM-RAD; pharmacokinetics of pioglitazone was carried out after RAD was 
      administrated to rats for 7 days. RESULTS: The established UPLC-MS/MS method was 
      rapid, specific, and precise. Between healthy and healthy-RAD groups, half-life 
      (T(1/2)), area under the curve (AUC (0-t)), Vz/F, and Cl/F showed mild yet 
      statistically significant differences; no significant difference for any above 
      parameter was detected between T2DM and T2DM-RAD groups. CONCLUSION: RAD 
      co-administration did not affect the pharmacokinetics of pioglitazone especially 
      in diabetic groups; RA and pioglitazone might be feasible herb-drug 
      co-effectiveness.
CI  - Copyright (c) 2012 Elsevier Ireland Ltd. All rights reserved.
FAU - Yuan, Yue-mei
AU  - Yuan YM
AD  - School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, PR China.
FAU - Gao, Jing-wen
AU  - Gao JW
FAU - Shi, Zhan
AU  - Shi Z
FAU - Huang, Ping
AU  - Huang P
FAU - Lu, Ya-song
AU  - Lu YS
FAU - Yao, Mei-cun
AU  - Yao MC
FAU - Huang, Min
AU  - Huang M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120928
PL  - Ireland
TA  - J Ethnopharmacol
JT  - Journal of ethnopharmacology
JID - 7903310
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Thiazolidinediones)
RN  - 922OP8YUPF (Huang Qi)
RN  - X4OV71U42S (Pioglitazone)
SB  - IM
MH  - Animals
MH  - Astragalus Plant
MH  - Astragalus propinquus
MH  - Diabetes Mellitus, Experimental/metabolism
MH  - Diabetes Mellitus, Type 2/metabolism
MH  - Drugs, Chinese Herbal/*pharmacology
MH  - *Herb-Drug Interactions
MH  - Hypoglycemic Agents/*pharmacokinetics
MH  - Male
MH  - Pioglitazone
MH  - Rats
MH  - Rats, Wistar
MH  - Thiazolidinediones/*pharmacokinetics
EDAT- 2012/10/03 06:00
MHDA- 2013/03/30 06:00
CRDT- 2012/10/03 06:00
PHST- 2012/05/14 00:00 [received]
PHST- 2012/08/30 00:00 [revised]
PHST- 2012/09/03 00:00 [accepted]
PHST- 2012/10/03 06:00 [entrez]
PHST- 2012/10/03 06:00 [pubmed]
PHST- 2013/03/30 06:00 [medline]
AID - S0378-8741(12)00607-1 [pii]
AID - 10.1016/j.jep.2012.09.012 [doi]
PST - ppublish
SO  - J Ethnopharmacol. 2012 Nov 21;144(2):300-4. doi: 10.1016/j.jep.2012.09.012. Epub 
      2012 Sep 28.