PMID- 23026378
OWN - NLM
STAT- MEDLINE
DCOM- 20130426
LR  - 20131121
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Linking)
VI  - 237
DP  - 2013 Jan 15
TI  - COMT and BDNF interacted in bipolar II disorder not comorbid with anxiety 
      disorder.
PG  - 243-8
LID - S0166-4328(12)00625-0 [pii]
LID - 10.1016/j.bbr.2012.09.039 [doi]
AB  - Bipolar disorder (BP), especially bipolar II disorder (BP-II), is highly comorbid 
      with anxiety disorder (AD). Monoaminergic dysfunction has been implicated in the 
      pathogenesis of BP, it may be important to investigate genes such as the 
      catechol-O-methyltransferase (COMT), involved in monoamine metabolism and 
      brain-derived neurotrophic factor (BDNF) genes, modulating the monoamine system. 
      We therefore examined the association of the COMT Val158Met and BDNF Val66Met 
      polymorphisms with BP-II with and without comorbidity of AD, and possible 
      interactions between these genes. Seven hundred and seventy-one participants were 
      recruited: 314 with bipolar-II without AD, 117 with bipolar-II with AD, and 340 
      healthy controls. The genotypes of the COMT and BDNF polymorphisms were 
      determined using polymerase chain reactions plus restriction fragment length 
      polymorphism analysis. Logistic regression analysis showed a significant effect 
      of the COMT and the BDNF polymorphisms, and a significant interaction effect for 
      the Val/Val genotypes of the BDNF Val66Met polymorphism and the COMsT Val158Met 
      Val/Met and Met/Met genotypes (P=0.007, 0.048) discriminated between BP-II 
      without AD patients and controls. Our findings provide initial evidence that the 
      COMT and BDNF genes interact in bipolar-II without AD. Our findings suggest the 
      involvement of dopaminergic pathway in the pathogenesis of bipolar-II.
CI  - Copyright (c) 2012 Elsevier B.V. All rights reserved.
FAU - Lee, Sheng-Yu
AU  - Lee SY
AD  - Department of Psychiatry, National Cheng Kung University, Tainan, Taiwan.
FAU - Chen, Shiou-Lan
AU  - Chen SL
FAU - Wang, Yu-Shan
AU  - Wang YS
FAU - Chang, Yun-Hsuan
AU  - Chang YH
FAU - Huang, San-Yuan
AU  - Huang SY
FAU - Tzeng, Nian-Sheng
AU  - Tzeng NS
FAU - Lee, I Hui
AU  - Lee IH
FAU - Yeh, Tzung Lieh
AU  - Yeh TL
FAU - Yang, Yen Kuang
AU  - Yang YK
FAU - Lu, Ru-Band
AU  - Lu RB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120929
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - AE28F7PNPL (Methionine)
RN  - EC 2.1.1.6 (Catechol O-Methyltransferase)
RN  - HG18B9YRS7 (Valine)
SB  - IM
MH  - Adult
MH  - Anxiety Disorders/complications/*genetics
MH  - Bipolar Disorder/complications/*genetics
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Catechol O-Methyltransferase/*genetics
MH  - Female
MH  - Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Methionine/genetics
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Valine/genetics
MH  - Young Adult
EDAT- 2012/10/03 06:00
MHDA- 2013/04/27 06:00
CRDT- 2012/10/03 06:00
PHST- 2012/08/10 00:00 [received]
PHST- 2012/09/18 00:00 [revised]
PHST- 2012/09/20 00:00 [accepted]
PHST- 2012/10/03 06:00 [entrez]
PHST- 2012/10/03 06:00 [pubmed]
PHST- 2013/04/27 06:00 [medline]
AID - S0166-4328(12)00625-0 [pii]
AID - 10.1016/j.bbr.2012.09.039 [doi]
PST - ppublish
SO  - Behav Brain Res. 2013 Jan 15;237:243-8. doi: 10.1016/j.bbr.2012.09.039. Epub 2012 
      Sep 29.