PMID- 23026490
OWN - NLM
STAT- MEDLINE
DCOM- 20130524
LR  - 20121203
IS  - 1873-4847 (Electronic)
IS  - 0955-2863 (Linking)
VI  - 24
IP  - 1
DP  - 2013 Jan
TI  - Mammary tumor development is directly inhibited by lifelong n-3 polyunsaturated 
      fatty acids.
PG  - 388-95
LID - S0955-2863(12)00209-4 [pii]
LID - 10.1016/j.jnutbio.2012.08.002 [doi]
AB  - INTRODUCTION: Despite the advocacy that diet may be a significant contributor to 
      cancer prevention, there is a lack of direct evidence from epidemiological and 
      experimental studies to substantiate such claims. Experimental studies suggest 
      that n-3 polyunsaturated fatty acids (n-3 PUFA) from marine oils may reduce 
      breast cancer risk, however, findings are equivocal. Thus, in this study, novel 
      transgenic mouse models were employed to provide, for the first time, direct 
      evidence for an anti-cancer role of n-3 PUFA in mammary tumorigenesis. METHODS: 
      fat-1 Mice, which are capable of endogenous n-3 PUFA synthesis, were bred with 
      mouse mammary tumor virus (MMTV)-neu(ndl)-YD5 mice, an aggressive breast cancer 
      model. The resultant offspring, including novel hybrid progeny, were assessed for 
      tumor onset, size and multiplicity as well as n-3 PUFA composition in mammary 
      gland and tumor tissue. A complementary group of MMTV-neu(ndl)-YD5 mice were fed 
      n-3 PUFA in the diet. RESULTS: Mice expressing MMTV-neu(ndl)-YD5 and fat-1 
      displayed significant (P<.05) reductions in tumor volume (~30%) and multiplicity 
      (~33%), as well as reduced n-6 PUFA and enriched n-3 PUFA in tumor phospholipids 
      relative to MMTV-neu(ndl)-YD5 control mice. The effect observed in hybrid progeny 
      was similarly observed in n-3 PUFA diet fed mice. CONCLUSION: Using complementary 
      genetic and conventional dietary approaches we provide, for the first time, 
      unequivocal experimental evidence that n-3 PUFA is causally linked to tumor 
      prevention.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - MacLennan, Mira B
AU  - MacLennan MB
AD  - Department of Human Health and Nutritional Sciences, University of Guelph, 
      Guelph, ON, Canada.
FAU - Clarke, Shannon E
AU  - Clarke SE
FAU - Perez, Kate
AU  - Perez K
FAU - Wood, Geoffrey A
AU  - Wood GA
FAU - Muller, William J
AU  - Muller WJ
FAU - Kang, Jing X
AU  - Kang JX
FAU - Ma, David W L
AU  - Ma DW
LA  - eng
GR  - MOP-89971/Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120929
PL  - United States
TA  - J Nutr Biochem
JT  - The Journal of nutritional biochemistry
JID - 9010081
RN  - 0 (Fatty Acids)
RN  - 0 (Fatty Acids, Omega-3)
SB  - IM
MH  - Animals
MH  - Body Weight/drug effects
MH  - Fatty Acids/analysis/chemistry
MH  - Fatty Acids, Omega-3/*pharmacology
MH  - Female
MH  - Male
MH  - Mammary Glands, Animal/chemistry
MH  - Mammary Neoplasms, Experimental/genetics/*pathology/*prevention & control
MH  - Mice
MH  - Mice, Transgenic
MH  - Organ Size/drug effects
EDAT- 2012/10/03 06:00
MHDA- 2013/05/28 06:00
CRDT- 2012/10/03 06:00
PHST- 2012/04/25 00:00 [received]
PHST- 2012/07/19 00:00 [revised]
PHST- 2012/08/01 00:00 [accepted]
PHST- 2012/10/03 06:00 [entrez]
PHST- 2012/10/03 06:00 [pubmed]
PHST- 2013/05/28 06:00 [medline]
AID - S0955-2863(12)00209-4 [pii]
AID - 10.1016/j.jnutbio.2012.08.002 [doi]
PST - ppublish
SO  - J Nutr Biochem. 2013 Jan;24(1):388-95. doi: 10.1016/j.jnutbio.2012.08.002. Epub 
      2012 Sep 29.