PMID- 23026836
OWN - NLM
STAT- MEDLINE
DCOM- 20130621
LR  - 20211021
IS  - 1933-6942 (Electronic)
IS  - 1933-6934 (Print)
IS  - 1933-6934 (Linking)
VI  - 6
IP  - 4
DP  - 2012 Oct-Dec
TI  - Abdominal segment reduction: development and evolution of a deeply fixed trait.
PG  - 240-5
LID - 10.4161/fly.22109 [doi]
AB  - When a new student first begins to push flies, an immediate skill that must be 
      learned is sorting the sexes. In Drosophila melanogaster several sexually 
      dimorphic characters can be used to readily distinguish males from females 
      including abdominal pigmentation, male sex combs and genital morphology. Another, 
      often-overlooked, sexual dimorphism is adult abdominal segment number. 
      Externally, adult Drosophila males possess one fewer abdominal segment than 
      females; the terminal pre-genital segment apparently either absent or fused with 
      the next-most anterior segment. Beyond known roles for the homeotic protein 
      Abdominal-B (Abd-B) and the sex-determining transcription factor Doublesex (Dsx) 
      as key regulators of this trait, surprisingly little is known about either the 
      morphogenetic processes or the downstream genetics responsible for patterning 
      these events. We have explored both and found that rapid epithelial 
      reorganization during pupation eliminates a nascent terminal male segment. We 
      found this Abd-B-dependent process results from sex- and segment-specific 
      regulation of diverse developmental targets including the wingless gene and 
      surprisingly, dsx itself. ( 1) (,) ( 2) Here, I review our observations and 
      discuss this trait as a model to explore both dynamics of epithelial 
      morphogenesis as well as the evolution of developmental mechanisms.
FAU - Yoder, John H
AU  - Yoder JH
AD  - Department of Biological Sciences, The University of Alabama, Tuscaloosa, AL, 
      USA. jhyoder@as.ua.edu
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
DEP - 20121001
PL  - United States
TA  - Fly (Austin)
JT  - Fly
JID - 101470897
RN  - 0 (Abd-B proteins, Drosophila)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (DSX protein, Drosophila)
RN  - 0 (Drosophila Proteins)
RN  - 0 (Homeodomain Proteins)
SB  - IM
CON - Wang W, Kidd BJ, Carroll SB, Yoder JH. Sexually dimorphic regulation of the 
      Wingless morphogen controls sex-specific segment number in Drosophila. Proc Natl 
      Acad Sci U S A. 2011;108:11139-44. doi: 10.1073/pnas.1108431108.
MH  - Animals
MH  - Body Patterning/*genetics
MH  - Body Size
MH  - Cell Differentiation
MH  - DNA-Binding Proteins/genetics/metabolism/physiology
MH  - Drosophila Proteins/genetics/metabolism/physiology
MH  - Drosophila melanogaster/anatomy & histology/genetics/*growth & development
MH  - Female
MH  - Homeodomain Proteins/genetics/metabolism/physiology
MH  - Male
MH  - Models, Biological
MH  - Morphogenesis/genetics
MH  - Sex Characteristics
PMC - PMC3519658
EDAT- 2012/10/03 06:00
MHDA- 2013/06/25 06:00
PMCR- 2013/10/01
CRDT- 2012/10/03 06:00
PHST- 2012/10/03 06:00 [entrez]
PHST- 2012/10/03 06:00 [pubmed]
PHST- 2013/06/25 06:00 [medline]
PHST- 2013/10/01 00:00 [pmc-release]
AID - 22109 [pii]
AID - 2012FLY0026R [pii]
AID - 10.4161/fly.22109 [doi]
PST - ppublish
SO  - Fly (Austin). 2012 Oct-Dec;6(4):240-5. doi: 10.4161/fly.22109. Epub 2012 Oct 1.