PMID- 23027509
OWN - NLM
STAT- MEDLINE
DCOM- 20141113
LR  - 20121002
IS  - 0036-7281 (Print)
IS  - 0036-7281 (Linking)
VI  - 154
IP  - 10
DP  - 2012 Oct
TI  - Risk factors causing postweaning multisystemic wasting syndrome (PMWS) onset in 
      Swiss pig farms.
PG  - 429-36
LID - 10.1024/0036-7281/a000379 [doi]
AB  - Postweaning multisystemic wasting syndrome (PMWS) was epizoozic between 2003 and 
      2008 in Switzerland. Nevertheless, infectious risk factors including porcine 
      reproductive and respiratory syndrome virus (PRRSV) were missing at all or were 
      seen only sporadically (enzootic pneumonia and actinobazillosis). In a 
      case-control study, 30 farms with PMWS affected pigs were compared to 30 
      inconspicious farms ("matched pairs"). The case-control allocation was verified 
      by PCV2 DNA measurements of 5 healthy weaned pigs in each control farm, 5 healthy 
      and 5 PMWS affected weaners in each PMWS affected farm. Diseased pigs showed in 
      average 1.8x10(8) DNA templates per ml serum significantly higher than healthy 
      pigs from control farms with 1x10(6) DNA templates per ml serum. Virus load in 
      healthy pigs did not differ between control- and PMWS affected farms. PMWS mainly 
      emerged among affected pigs in the 5th to 8th week of age. In a logistic 
      regression model risk factors were identified such as high occupancy in weaning 
      pens (p = 0.002), large groups in gestation facilities (p = 0.03) as well as 
      reduced birth weight < 1.3 kg (p = 0.04). We suggest these factors might have 
      lead to chronic stress e.g. through influencing negatively social interaction in 
      pigs or disturbances of the maturing immune system. Heavy fly and rodent 
      infestation might not only be viewed as a vector for disease transmission, but, 
      also as a stress factor.
FAU - Baumgartner, M
AU  - Baumgartner M
AD  - Department for Farm Animals, University of Zurich, Switzerland.
FAU - Brugnera, E
AU  - Brugnera E
FAU - Sydler, T
AU  - Sydler T
FAU - Burgi, E
AU  - Burgi E
FAU - Hassig, M
AU  - Hassig M
FAU - Sidler, X
AU  - Sidler X
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Schweiz Arch Tierheilkd
JT  - Schweizer Archiv fur Tierheilkunde
JID - 0424247
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Animals
MH  - Case-Control Studies
MH  - DNA, Viral/blood
MH  - Porcine Postweaning Multisystemic Wasting Syndrome/blood/*epidemiology/virology
MH  - Risk Factors
MH  - Sus scrofa
MH  - Swine
MH  - Switzerland/epidemiology
MH  - Viral Load
EDAT- 2012/10/03 06:00
MHDA- 2014/11/14 06:00
CRDT- 2012/10/03 06:00
PHST- 2012/10/03 06:00 [entrez]
PHST- 2012/10/03 06:00 [pubmed]
PHST- 2014/11/14 06:00 [medline]
AID - 10.1024/0036-7281/a000379 [doi]
PST - ppublish
SO  - Schweiz Arch Tierheilkd. 2012 Oct;154(10):429-36. doi: 10.1024/0036-7281/a000379.