PMID- 23030067
OWN - NLM
STAT- MEDLINE
DCOM- 20130521
LR  - 20221207
IS  - 1366-5804 (Electronic)
IS  - 1354-750X (Linking)
VI  - 17
IP  - 8
DP  - 2012 Dec
TI  - The combined effect of persistent organic pollutants in the serum POP mixture in 
      Greenlandic Inuit: xenoestrogenic, xenoandrogenic and dioxin-like 
      transactivities.
PG  - 692-705
LID - 10.3109/1354750X.2012.700950 [doi]
AB  - Greenlandic Inuit have high body burden of persistent organic pollutants (POPs). 
      We analyzed the combined effect of the actual lipophilic serum POP mixture on 
      estrogen-, androgen- and aryl hydrocarbon-receptor functions as effect 
      biomarkers, and the associations between the effect biomarkers and serum POPs, 
      and lifestyle characteristics. The serum POPs were extracted from 232 Inuit from 
      Ittoqqortoormiit, Narsaq and Qeqertarsuaq. The POP-related receptor 
      transactivities correlated negatively to the POP levels and were associated to 
      the lifestyle characteristics. The POP-related receptor transactivities can be 
      used as effect biomarkers. The serum POPs have hormone disruptive potentials.
FAU - Kruger, Tanja
AU  - Kruger T
AD  - Department of Public Health, Centre for Arctic Health & Cellular and Molecular 
      Toxicology, Aarhus University, Aarhus C, Denmark.
FAU - Long, Manhai
AU  - Long M
FAU - Ghisari, Mandana
AU  - Ghisari M
FAU - Bonefeld-Jorgensen, Eva C
AU  - Bonefeld-Jorgensen EC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121003
PL  - England
TA  - Biomarkers
JT  - Biomarkers : biochemical indicators of exposure, response, and susceptibility to 
      chemicals
JID - 9606000
RN  - 0 (Biomarkers)
RN  - 0 (Dioxins)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Organic Chemicals)
RN  - 0 (Receptors, Androgen)
RN  - 0 (Receptors, Aryl Hydrocarbon)
RN  - 0 (Receptors, Estrogen)
RN  - 0 (Xenobiotics)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Analysis of Variance
MH  - Biomarkers/blood
MH  - Dioxins/blood
MH  - Environmental Pollutants/*blood
MH  - Female
MH  - Geography
MH  - Greenland
MH  - Humans
MH  - *Inuit
MH  - Life Style
MH  - Male
MH  - Middle Aged
MH  - Organic Chemicals/blood
MH  - Polychlorinated Biphenyls/blood
MH  - Receptors, Androgen/*blood
MH  - Receptors, Aryl Hydrocarbon/*blood
MH  - Receptors, Estrogen/*blood
MH  - Xenobiotics/blood
MH  - Young Adult
EDAT- 2012/10/04 06:00
MHDA- 2013/05/23 06:00
CRDT- 2012/10/04 06:00
PHST- 2012/10/04 06:00 [entrez]
PHST- 2012/10/04 06:00 [pubmed]
PHST- 2013/05/23 06:00 [medline]
AID - 10.3109/1354750X.2012.700950 [doi]
PST - ppublish
SO  - Biomarkers. 2012 Dec;17(8):692-705. doi: 10.3109/1354750X.2012.700950. Epub 2012 
      Oct 3.