PMID- 23030765
OWN - NLM
STAT- MEDLINE
DCOM- 20130717
LR  - 20220410
IS  - 1476-4954 (Electronic)
IS  - 1476-4954 (Linking)
VI  - 26
IP  - 3
DP  - 2013 Feb
TI  - Short-term and long-term sequelae in intrauterine growth retardation (IUGR).
PG  - 222-5
LID - 10.3109/14767058.2012.715006 [doi]
AB  - Intrauterine Growth Retardation (IUGR) is defined as a rate of growth of a fetus 
      that is less than normal for the growth potential of the fetus (for that 
      particular gestational age). Small for Gestational Age (SGA) is defined infant 
      born following IUGR, with a weight at birth below the 10th percentile.Suboptimal 
      fetal growth occurring in IUGR fetuses is an important cause of perinatal 
      mortality and morbidity. The acute neonatal consequences of IUGR include 
      metabolic and hematological disturbances, and disrupted thermoregulation; in 
      addition, respiratory distress (RDS), necrotizing enterocolitis (NEC), and 
      retinopathy of prematurity (ROP) may contribute to perinatal morbidity. Metabolic 
      disturbances are related to glucose and fatty acid metabolism. It is well-known 
      that individuals who display poor growth in utero are at significantly increased 
      risk for type 2 diabetes mellitus (T2DM), obesity, hypertension, dyslipidemia, 
      and insulin resistance (the so-called metabolic syndrome, MS). MS ultimately 
      leads to the premature development of cardiovascular diseases. In addition, short 
      stature in children and adults, premature adrenarche, and the polycystic ovarian 
      syndrome (PCOS) are endocrinological sequelae of IUGR. (8) Early onset growth 
      delay and prematurity significantly increase the risk for neurological sequelae 
      and motor and cognitive delay.Future prospective studies need to investigate risk 
      factors for infants who are SGA. If reliable prediction can be achieved, there is 
      potential to reduce future perinatal morbidity and mortality, and long term 
      consequences among SGA babies.
FAU - Longo, Stefania
AU  - Longo S
AD  - Neonatal Intensive Care Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, 
      Italy. sty.longo@gmail.com
FAU - Bollani, Lina
AU  - Bollani L
FAU - Decembrino, Lidia
AU  - Decembrino L
FAU - Di Comite, Amelia
AU  - Di Comite A
FAU - Angelini, Mauro
AU  - Angelini M
FAU - Stronati, M
AU  - Stronati M
LA  - eng
PT  - Journal Article
DEP - 20121003
PL  - England
TA  - J Matern Fetal Neonatal Med
JT  - The journal of maternal-fetal & neonatal medicine : the official journal of the 
      European Association of Perinatal Medicine, the Federation of Asia and Oceania 
      Perinatal Societies, the International Society of Perinatal Obstetricians
JID - 101136916
SB  - IM
MH  - Adult
MH  - Endocrine System Diseases/epidemiology/etiology
MH  - Female
MH  - Fetal Growth Retardation/*epidemiology/*physiopathology
MH  - Humans
MH  - Infant, Newborn
MH  - Infant, Newborn, Diseases/epidemiology/etiology
MH  - Infant, Small for Gestational Age/physiology
MH  - Mental Disorders/epidemiology/etiology
MH  - Metabolic Diseases/epidemiology/etiology
MH  - Morbidity
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/*epidemiology/etiology
MH  - Time Factors
EDAT- 2012/10/04 06:00
MHDA- 2013/07/19 06:00
CRDT- 2012/10/04 06:00
PHST- 2012/10/04 06:00 [entrez]
PHST- 2012/10/04 06:00 [pubmed]
PHST- 2013/07/19 06:00 [medline]
AID - 10.3109/14767058.2012.715006 [doi]
PST - ppublish
SO  - J Matern Fetal Neonatal Med. 2013 Feb;26(3):222-5. doi: 
      10.3109/14767058.2012.715006. Epub 2012 Oct 3.