PMID- 23033662
OWN - NLM
STAT- MEDLINE
DCOM- 20130312
LR  - 20121004
IS  - 1004-5619 (Print)
IS  - 1004-5619 (Linking)
VI  - 28
IP  - 4
DP  - 2012 Aug
TI  - [Magnetic resonance diffusion tensor imaging for diagnosis of pyramidal tract 
      damage in rats].
PG  - 256-60, 268
AB  - OBJECTIVE: To explore the applicability of magnetic resonance diffusion tensor 
      imaging (DTI) for diagnosis of pyramidal tract damage in rats. METHODS: 
      Marmarou's model was set up, followed by DTI scanning at 3, 12, 24 and 72 h post 
      trauma to acquire the dispersion parameter of bilateral pyramidal tracts. 
      Moreover, axonal varicosities per square millimeter and the percentage of 
      positive area of axons demonstrated by beta-amyloid precursor protein (beta-APP) 
      immunostaining were obtained, as well as the mean density and sum density of 
      neurofilament (NF) 68 immunostaining. RESULTS: Axial diffusivity (AD), fraction 
      anisotropy (FA) and relative anisotropy (RA) in the pyramidal tract were 
      significantly and continuously reduced and reached to the bottom at 72h post 
      trauma (P < 0.05) in accord with the gradient of axonal damage verified by 
      beta-APP and NF68 immunostaining. Furthermore, the changes of AD, FA and RA 
      showed a significant negative correlation with the beta-APP immunohistochemical 
      results. CONCLUSION: DTI has important value for early diagnosis in pyramidal 
      tract damage.
FAU - Li, Shang-Xun
AU  - Li SX
AD  - Department of Forensic Medicine, Tongji Medical College, Huazhong University of 
      Science and Technology, Wuhan 430030, China. lishangxun@gmail.com
FAU - Shan, Dai
AU  - Shan D
FAU - Duan, Yi-Jie
AU  - Duan YJ
FAU - Xing, Jing-Jun
AU  - Xing JJ
FAU - Ding, Yang
AU  - Ding Y
FAU - Zhou, Yi-Wu
AU  - Zhou YW
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Fa Yi Xue Za Zhi
JT  - Fa yi xue za zhi
JID - 9426151
RN  - 0 (Amyloid beta-Protein Precursor)
RN  - 0 (Neurofilament Proteins)
RN  - 0 (neurofilament protein NF 68)
SB  - IM
MH  - Amyloid beta-Protein Precursor/metabolism
MH  - Animals
MH  - Anisotropy
MH  - Axons/pathology
MH  - Brain/metabolism/*pathology
MH  - Brain Injuries/*diagnosis/metabolism/pathology
MH  - Diffusion Magnetic Resonance Imaging/*methods
MH  - Disease Models, Animal
MH  - Image Processing, Computer-Assisted
MH  - Male
MH  - Neurofilament Proteins/metabolism
MH  - Pyramidal Tracts/metabolism/*pathology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Severity of Illness Index
MH  - Time Factors
EDAT- 2012/10/05 06:00
MHDA- 2013/03/13 06:00
CRDT- 2012/10/05 06:00
PHST- 2012/10/05 06:00 [entrez]
PHST- 2012/10/05 06:00 [pubmed]
PHST- 2013/03/13 06:00 [medline]
PST - ppublish
SO  - Fa Yi Xue Za Zhi. 2012 Aug;28(4):256-60, 268.