PMID- 23033888
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130129
LR  - 20211021
IS  - 1472-6769 (Electronic)
IS  - 1472-6769 (Linking)
VI  - 12
DP  - 2012 Oct 3
TI  - Anti-cancer activity of novel dibenzo[b,f]azepine tethered isoxazoline 
      derivatives.
PG  - 5
LID - 10.1186/1472-6769-12-5 [doi]
AB  - BACKGROUND: Dibenzoazepine (DB) derivatives are important and valuable compounds 
      in medicinal chemistry. The synthesis and chemotherapeutic properties of 
      naturally occurring DBs and different heterocyclic moiety tethered DBs are 
      reported. Herein, we report the DB-fused hybrid structure that containing 
      isoxazolines (DBIs) and their anti-cancer activity, which could throw light on 
      the structural and functional features of new molecules. RESULTS AND CONCLUSION: 
      The synthesis and characterization of novel ring DB tethered isoxazoline 
      derivatives (DBIs) were carried out. After the detailed structural 
      characterization using 2D-NMR experiments, the compounds were identified as 
      5-substituted isoxazolines. The effect of newly synthesized DBIs against the 
      invasion of murine osteosarcoma (LM8G7) cells was studied. Among the tested 
      molecules, compound 4g 
      (5-[-3-(4-chlorophenyl)-4,5-dihydroisoxazol-5-yl-methyl]-5 H-dibenzo[b,f]azepine), 
      was found to inhibit the invasion of LM8G7 cells strongly, when compared to other 
      structurally related compounds. Cumulatively, the compound 4g inhibited the 
      invasion MDA-MB-231 cells completely at 10 muM. In addition to anti-invasion 
      property the compound 4g also inhibited the migration of LM8G7 and human ovarian 
      cancer cells (OVSAHO) dose-dependently. Compound 4g inhibited the proliferation 
      of LM8G7, OVSAHO, human breast cancer cells (MCF-7) and human melphalan-resistant 
      multiple myeloma (RPMI8226-LR5) cells that are comparable to cisplatin and 
      suramin.
FAU - Sadashiva, Maralinganadoddi Panchegowda
AU  - Sadashiva MP
AD  - Department of Studies in Chemistry, University of Mysore, Mysore, 570006, India.
FAU - Basappa
AU  - Basappa
AD  - Laboratory of Proteoglycan Signalling and Therapeutics, Faculty of Advanced Life 
      Science, Hokkaido University Graduate School of Life Science, Sapporo, 110021, 
      Japan.
AD  - Department of Chemistry, Central College Campus, Bangalore University, Bangalore, 
      560001, India.
FAU - NanjundaSwamy, Shivananju
AU  - NanjundaSwamy S
AD  - Department of Pharmacology, Yong Loo Lin School of Medicine, National University 
      of Singapore, Kent Ridge, Singapore, 117597.
FAU - Li, Feng
AU  - Li F
AD  - Department of Pharmacology, Yong Loo Lin School of Medicine, National University 
      of Singapore, Kent Ridge, Singapore, 117597.
FAU - Manu, Kanjoormana Aryan
AU  - Manu KA
AD  - Department of Pharmacology, Yong Loo Lin School of Medicine, National University 
      of Singapore, Kent Ridge, Singapore, 117597.
FAU - Sengottuvelan, Murugan
AU  - Sengottuvelan M
AD  - Laboratory of Proteoglycan Signalling and Therapeutics, Faculty of Advanced Life 
      Science, Hokkaido University Graduate School of Life Science, Sapporo, 110021, 
      Japan.
FAU - Prasanna, Doddakunche Shivaramu
AU  - Prasanna DS
AD  - Department of Studies in Chemistry, University of Mysore, Mysore, 570006, India.
FAU - Anilkumar, Nirvanappa Chikkagundagal
AU  - Anilkumar NC
AD  - Department of Chemistry, Central College Campus, Bangalore University, Bangalore, 
      560001, India.
FAU - Sethi, Gautam
AU  - Sethi G
AD  - Department of Pharmacology, Yong Loo Lin School of Medicine, National University 
      of Singapore, Kent Ridge, Singapore, 117597.
FAU - Sugahara, Kazuyuki
AU  - Sugahara K
AD  - Laboratory of Proteoglycan Signalling and Therapeutics, Faculty of Advanced Life 
      Science, Hokkaido University Graduate School of Life Science, Sapporo, 110021, 
      Japan.
FAU - Rangappa, Kanchugarakoppal Subbegowda
AU  - Rangappa KS
AD  - Department of Studies in Chemistry, University of Mysore, Mysore, 570006, India.
LA  - eng
PT  - Journal Article
DEP - 20121003
PL  - England
TA  - BMC Chem Biol
JT  - BMC chemical biology
JID - 101088664
PMC - PMC3554437
EDAT- 2012/10/05 06:00
MHDA- 2012/10/05 06:01
PMCR- 2012/10/03
CRDT- 2012/10/05 06:00
PHST- 2012/02/06 00:00 [received]
PHST- 2012/09/03 00:00 [accepted]
PHST- 2012/10/05 06:00 [entrez]
PHST- 2012/10/05 06:00 [pubmed]
PHST- 2012/10/05 06:01 [medline]
PHST- 2012/10/03 00:00 [pmc-release]
AID - 1472-6769-12-5 [pii]
AID - 10.1186/1472-6769-12-5 [doi]
PST - epublish
SO  - BMC Chem Biol. 2012 Oct 3;12:5. doi: 10.1186/1472-6769-12-5.