PMID- 23033912
OWN - NLM
STAT- MEDLINE
DCOM- 20130306
LR  - 20130102
IS  - 1365-3083 (Electronic)
IS  - 0300-9475 (Linking)
VI  - 77
IP  - 1
DP  - 2013 Jan
TI  - Interferon regulation factor-3 is a critical regulator of the mature of dendritic 
      cells from mice.
PG  - 13-20
LID - 10.1111/sji.12005 [doi]
AB  - Interferon regulatory factor-3 (IRF-3) plays an important role in virus and 
      double-stranded RNA-mediated induction of type I interferon and RANTES (regulated 
      on activation normal T cell expressed and secreted), DNA damage signalling, 
      tumour suppression and virus-induced apoptosis. IRF-3 had recently been shown to 
      contribute to T-cell activation in response to pathogens, which implicated an 
      extensive immunological role for IRF-3. Dendritic cells (DCs) played critical 
      roles as professional APCs in the development of immune responses. However, it 
      was unclear whether IRF-3 had any effect on phenotype or function of DCs. In this 
      study, it was shown that IRF-3 acted as a promoter of DC maturation. The level of 
      IRF-3 expression was transiently upregulated and accumulated in the nucleus in 
      TNF-alpha-induced immune maturation of mice DC cells. Knockdown of IRF-3 by small 
      interfering RNA in DC cells resulted in both phenotypic and functional 
      immaturation, even without TNF-alpha treatment. Overall, our data demonstrated for 
      the first time that IRF-3 was a critical regulator of mice DC maturation.
CI  - (c) 2012 The Authors. Scandinavian Journal of Immunology (c) 2012 Blackwell 
      Publishing Ltd.
FAU - Zhang, G
AU  - Zhang G
AD  - Department of Hematology, Shengjing Hospital of China Medical University, 
      Shenyang, China.
FAU - Zhang, Z
AU  - Zhang Z
FAU - Liu, Z
AU  - Liu Z
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Scand J Immunol
JT  - Scandinavian journal of immunology
JID - 0323767
RN  - 0 (Interferon Regulatory Factor-3)
RN  - 0 (RNA, Small Interfering)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Animals
MH  - Antigen Presentation
MH  - Cell Differentiation/genetics
MH  - Cells, Cultured
MH  - Dendritic Cells/*immunology
MH  - Female
MH  - Humans
MH  - Interferon Regulatory Factor-3/genetics/immunology/*metabolism
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - RNA, Small Interfering/genetics
MH  - Tumor Necrosis Factor-alpha/immunology
EDAT- 2012/10/05 06:00
MHDA- 2013/03/07 06:00
CRDT- 2012/10/05 06:00
PHST- 2012/04/18 00:00 [received]
PHST- 2012/09/24 00:00 [accepted]
PHST- 2012/10/05 06:00 [entrez]
PHST- 2012/10/05 06:00 [pubmed]
PHST- 2013/03/07 06:00 [medline]
AID - 10.1111/sji.12005 [doi]
PST - ppublish
SO  - Scand J Immunol. 2013 Jan;77(1):13-20. doi: 10.1111/sji.12005.