PMID- 23035593
OWN - NLM
STAT- MEDLINE
DCOM- 20121101
LR  - 20191112
IS  - 2041-5990 (Print)
IS  - 2041-5990 (Linking)
VI  - 3
IP  - 9
DP  - 2012 Sep
TI  - Functional RNA delivery targeted to dendritic cells by synthetic nanoparticles.
PG  - 1077-99
AB  - Dendritic cells (DCs) are essential to many aspects of immune defense development 
      and regulation. They provide important targets for prophylactic and therapeutic 
      delivery. While protein delivery has had considerable success, RNA delivery is 
      still expanding. Delivering RNA molecules for RNAi has shown particular success 
      and there are reports on successful delivery of mRNA. Central, therein, is the 
      application of cationic entities. Following endocytosis of the delivery vehicle 
      for the RNA, cationic entities should promote vesicular membrane perturbation, 
      facilitating cytosolic release. The present review explains the diversity of DC 
      function in immune response development and control. Promotion of delivered RNA 
      cytosolic release is discussed, relating to immunoprophylactic and therapeutic 
      potential, and DC endocytic machinery is reviewed, showing how DC endocytic 
      pathways influence the handling of internalized material. The potential 
      advantages for application of replicating RNA are presented and discussed, in 
      consideration of their value and development in the near future.
FAU - McCullough, Kenneth C
AU  - McCullough KC
AD  - Institute of Virology & Immunoprophylaxis, CH-3147 Mittelhausern, Switzerland. 
      kmc.projectsl@gmail.com
FAU - Bassi, Isabelle
AU  - Bassi I
FAU - Demoulins, Thomas
AU  - Demoulins T
FAU - Thomann-Harwood, Lisa J
AU  - Thomann-Harwood LJ
FAU - Ruggli, Nicolas
AU  - Ruggli N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Ther Deliv
JT  - Therapeutic delivery
JID - 101538870
RN  - 63231-63-0 (RNA)
SB  - IM
MH  - Animals
MH  - Antigen Presentation
MH  - Dendritic Cells/*metabolism
MH  - Humans
MH  - Hydrogen-Ion Concentration
MH  - Immune Tolerance
MH  - Nanoparticles/*administration & dosage
MH  - RNA/*administration & dosage
MH  - RNA Interference
MH  - Transport Vesicles/metabolism
EDAT- 2012/10/06 06:00
MHDA- 2012/11/02 06:00
CRDT- 2012/10/06 06:00
PHST- 2012/10/06 06:00 [entrez]
PHST- 2012/10/06 06:00 [pubmed]
PHST- 2012/11/02 06:00 [medline]
AID - 10.4155/tde.12.90 [doi]
PST - ppublish
SO  - Ther Deliv. 2012 Sep;3(9):1077-99. doi: 10.4155/tde.12.90.