PMID- 23035701
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121128
LR  - 20240321
IS  - 1550-2783 (Electronic)
IS  - 1550-2783 (Linking)
VI  - 9
IP  - 1
DP  - 2012 Oct 5
TI  - Efficacy of phosphatidic acid ingestion on lean body mass, muscle thickness and 
      strength gains in resistance-trained men.
PG  - 47
LID - 10.1186/1550-2783-9-47 [doi]
AB  - BACKGROUND: Phosphatidic acid (PA) has been reported to activate the mammalian 
      target of rapamycin (mTOR) signaling pathway and is thought to enhance the 
      anabolic effects of resistance training. The purpose of this pilot study was to 
      examine if oral phosphatidic acid administration can enhance strength, muscle 
      thickness and lean tissue accruement during an 8-week resistance training 
      program. METHODS: Sixteen resistance-trained men were randomly assigned to a 
      group that either consumed 750 mg of PA (n = 7, 23.1 +/- 4.4 y; 176.7 +/- 6.7 cm; 
      86.5 +/- 21.2 kg) or a placebo (PL, n = 9, 22.5 +/- 2.0 y; 179.8 +/- 5.4 cm; 
      89.4 +/- 13.6 kg) group. During each testing session subjects were assessed for 
      strength (one repetition maximum [1-RM] bench press and squat) and body 
      composition. Muscle thickness and pennation angle were also measured in the 
      vastus lateralis of the subject's dominant leg. RESULTS: Subjects ingesting PA 
      demonstrated a 12.7% increase in squat strength and a 2.6% increase in LBM, while 
      subjects consuming PL showed a 9.3% improvement in squat strength and a 0.1% 
      change in LBM. Although parametric analysis was unable to demonstrate significant 
      differences, magnitude based inferences indicated that the Delta change in 1-RM squat 
      showed a likely benefit from PA on increasing lower body strength and a very 
      likely benefit for increasing lean body mass (LBM). CONCLUSIONS: Results of this 
      study suggest that a combination of a daily 750 mg PA ingestion, combined with a 
      4-day per week resistance training program for 8-weeks appears to have a likely 
      benefit on strength improvement, and a very likely benefit on lean tissue 
      accruement in young, resistance trained individuals.
FAU - Hoffman, Jay R
AU  - Hoffman JR
AD  - Human Performance Laboratory, University of Central Florida, Orlando, 32186, FL, 
      USA. Jay.Hoffman@ucf.edu.
FAU - Stout, Jeffrey R
AU  - Stout JR
FAU - Williams, David R
AU  - Williams DR
FAU - Wells, Adam J
AU  - Wells AJ
FAU - Fragala, Maren S
AU  - Fragala MS
FAU - Mangine, Gerald T
AU  - Mangine GT
FAU - Gonzalez, Adam M
AU  - Gonzalez AM
FAU - Emerson, Nadia S
AU  - Emerson NS
FAU - McCormack, William P
AU  - McCormack WP
FAU - Scanlon, Tyler C
AU  - Scanlon TC
FAU - Purpura, Martin
AU  - Purpura M
FAU - Jager, Ralf
AU  - Jager R
LA  - eng
PT  - Journal Article
DEP - 20121005
PL  - United States
TA  - J Int Soc Sports Nutr
JT  - Journal of the International Society of Sports Nutrition
JID - 101234168
PMC - PMC3506449
EDAT- 2012/10/06 06:00
MHDA- 2012/10/06 06:01
PMCR- 2012/10/05
CRDT- 2012/10/06 06:00
PHST- 2012/08/24 00:00 [received]
PHST- 2012/09/26 00:00 [accepted]
PHST- 2012/10/06 06:00 [entrez]
PHST- 2012/10/06 06:00 [pubmed]
PHST- 2012/10/06 06:01 [medline]
PHST- 2012/10/05 00:00 [pmc-release]
AID - 1550-2783-9-47 [pii]
AID - 10.1186/1550-2783-9-47 [doi]
PST - epublish
SO  - J Int Soc Sports Nutr. 2012 Oct 5;9(1):47. doi: 10.1186/1550-2783-9-47.