PMID- 23036175 OWN - NLM STAT- MEDLINE DCOM- 20131230 LR - 20151119 IS - 1532-2971 (Electronic) IS - 1090-0233 (Linking) VI - 196 IP - 2 DP - 2013 May TI - Assessment of oxidative stress biomarkers in exhaled breath condensate and blood of Thoroughbred foals. PG - 269-71 LID - S1090-0233(12)00367-X [pii] LID - 10.1016/j.tvjl.2012.08.018 [doi] AB - This study reports preliminary data on systemic and local biomarkers of oxidative stress (OS) in Thoroughbred foals. Blood and exhaled breath condensate (EBC) were sampled from 13 foals on two farms. Values of reactive oxygen metabolites (d-ROMs), biological antioxidant potential (BAP), antioxidant barrier (OXY-ads), thiol antioxidant barrier (SHp) and advanced oxidation protein products (AOPPs) were determined in blood, while EBC samples were assayed for hydrogen peroxide (H(2)O(2)) levels. Systemic and local OS biomarkers did not differ between farms and gender. Increased oxidative stress index (OSI) values in a foal recovering from pneumonia and elevated H(2)O(2) in EBC coupled with low SHp and elevated AOPPs in the blood of a foal with overt upper respiratory tract disease suggested that the OS markers measured in this study may relate to the respiratory health status of foals. CI - Copyright (c) 2012 Elsevier Ltd. All rights reserved. FAU - Po, Eleonora AU - Po E AD - Faculty of Veterinary Science, The University of Sydney, PMB 4003, Narellan, NSW 2567, Australia. FAU - Williams, Claire AU - Williams C FAU - Muscatello, Gary AU - Muscatello G FAU - Celi, Pietro AU - Celi P LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20121001 PL - England TA - Vet J JT - Veterinary journal (London, England : 1997) JID - 9706281 RN - 0 (Biomarkers) SB - IM MH - Animals MH - Biomarkers/analysis/blood MH - Breath Tests/*methods MH - Female MH - Horse Diseases/blood/*metabolism MH - Horses MH - Male MH - Oxidative Stress/*physiology MH - Pneumonia/blood/metabolism/*veterinary MH - Respiratory Tract Infections/blood/metabolism/*veterinary EDAT- 2012/10/06 06:00 MHDA- 2014/01/01 06:00 CRDT- 2012/10/06 06:00 PHST- 2012/03/20 00:00 [received] PHST- 2012/08/27 00:00 [revised] PHST- 2012/08/28 00:00 [accepted] PHST- 2012/10/06 06:00 [entrez] PHST- 2012/10/06 06:00 [pubmed] PHST- 2014/01/01 06:00 [medline] AID - S1090-0233(12)00367-X [pii] AID - 10.1016/j.tvjl.2012.08.018 [doi] PST - ppublish SO - Vet J. 2013 May;196(2):269-71. doi: 10.1016/j.tvjl.2012.08.018. Epub 2012 Oct 1.