PMID- 23036620
OWN - NLM
STAT- MEDLINE
DCOM- 20131017
LR  - 20211021
IS  - 1873-7544 (Electronic)
IS  - 0306-4522 (Print)
IS  - 0306-4522 (Linking)
VI  - 239
DP  - 2013 Jun 3
TI  - Progesterone, brain-derived neurotrophic factor and neuroprotection.
PG  - 84-91
LID - S0306-4522(12)00976-1 [pii]
LID - 10.1016/j.neuroscience.2012.09.056 [doi]
AB  - While the effects of progesterone in the CNS, like those of estrogen, have 
      generally been considered within the context of reproductive function, growing 
      evidence supports its importance in regulating non-reproductive functions 
      including cognition and affect. In addition, progesterone has well-described 
      protective effects against numerous insults in a variety of cell models, animal 
      models and in humans. While ongoing research in several laboratories continues to 
      shed light on the mechanism(s) by which progesterone and its related progestins 
      exert their effects in the CNS, our understanding is still incomplete. Among the 
      key mediators of progesterone's beneficial effects is the family of growth 
      factors called neurotrophins. Here, we review the mechanisms by which 
      progesterone regulates one important member of the neurotrophin family, 
      brain-derived neurotrophic factor (BDNF), and provides support for its pivotal 
      role in the protective program elicited by progesterone in the brain.
CI  - Copyright (c) 2012 IBRO. Published by Elsevier Ltd. All rights reserved.
FAU - Singh, M
AU  - Singh M
AD  - Department of Pharmacology and Neuroscience, Institute for Aging and Alzheimer's 
      Disease Research, Center FOR HER, University of North Texas Health Science Center 
      at Fort Worth, Fort Worth, TX 76107, USA. meharvan.singh@unthsc.edu
FAU - Su, C
AU  - Su C
LA  - eng
GR  - P01 AG022550/AG/NIA NIH HHS/United States
GR  - P01 AG027956/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20121002
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Neuroprotective Agents)
RN  - 4G7DS2Q64Y (Progesterone)
SB  - IM
MH  - Animals
MH  - Brain/*metabolism
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Humans
MH  - Neuroprotective Agents/pharmacology
MH  - Progesterone/*metabolism/pharmacology
PMC - PMC3582842
MID - NIHMS421548
EDAT- 2012/10/06 06:00
MHDA- 2013/10/18 06:00
PMCR- 2014/06/03
CRDT- 2012/10/06 06:00
PHST- 2012/07/26 00:00 [received]
PHST- 2012/09/20 00:00 [revised]
PHST- 2012/09/23 00:00 [accepted]
PHST- 2012/10/06 06:00 [entrez]
PHST- 2012/10/06 06:00 [pubmed]
PHST- 2013/10/18 06:00 [medline]
PHST- 2014/06/03 00:00 [pmc-release]
AID - S0306-4522(12)00976-1 [pii]
AID - 10.1016/j.neuroscience.2012.09.056 [doi]
PST - ppublish
SO  - Neuroscience. 2013 Jun 3;239:84-91. doi: 10.1016/j.neuroscience.2012.09.056. Epub 
      2012 Oct 2.