PMID- 23038034
OWN - NLM
STAT- MEDLINE
DCOM- 20130122
LR  - 20131121
IS  - 1536-4798 (Electronic)
IS  - 0277-3740 (Linking)
VI  - 31 Suppl 1
DP  - 2012 Nov
TI  - Meibomitis-related keratoconjunctivitis: implications and clinical significance 
      of meibomian gland inflammation.
PG  - S41-4
LID - 10.1097/ICO.0b013e31826a04dd [doi]
AB  - Meibomian gland inflammation, "meibomitis," is associated with ocular surface 
      inflammatory diseases. However, these diseases are poorly defined clinically, 
      making effective treatment difficult. Herein, we propose a new disease subset, 
      termed meibomitis-related keratoconjunctivitis (MRKC). The ocular surface 
      features of MRKC include: meibomitis with redness and swelling of the eyelid 
      margin and palpebral conjunctiva; superficial vascularization and granulomatous 
      nodules in the cornea; and conjunctival hyperemia, similar or identical to that 
      observed in phlyctenular keratitis. The characteristics of MRKC patients include 
      a significantly higher prevalence in women, multiple history of chalazia, close 
      association with meibomitis, the presence of specific human leukocyte antigen 
      association, high Propionibacterium acnes detection rates in meibum culture, and 
      the effectiveness of systemic antimicrobial therapy targeting P. acnes. MRKC may 
      share many clinical features with ocular rosacea, especially during childhood. 
      The clinical effectiveness of systemic antimicrobial agents in treating both 
      diseases suggests the importance of focusing on the elimination of bacteria such 
      as P. acnes.
FAU - Suzuki, Tomo
AU  - Suzuki T
AD  - Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, 
      Japan. tomosuzu@koto.kpu-m.ac.jp
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Cornea
JT  - Cornea
JID - 8216186
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Cephalosporins)
RN  - H1250JIK0A (Clarithromycin)
SB  - IM
MH  - Age Factors
MH  - Anti-Bacterial Agents/therapeutic use
MH  - Blepharitis/drug therapy/epidemiology/*etiology
MH  - Cephalosporins/therapeutic use
MH  - Clarithromycin/therapeutic use
MH  - Eye Infections, Bacterial/complications/drug therapy/epidemiology
MH  - Gram-Positive Bacterial Infections/complications/drug therapy/epidemiology
MH  - Humans
MH  - Keratoconjunctivitis/drug therapy/epidemiology/*etiology
MH  - Meibomian Glands/*pathology
MH  - Prevalence
MH  - Propionibacterium acnes/isolation & purification
MH  - Sex Factors
EDAT- 2012/10/17 06:00
MHDA- 2013/01/23 06:00
CRDT- 2012/10/06 06:00
PHST- 2012/10/06 06:00 [entrez]
PHST- 2012/10/17 06:00 [pubmed]
PHST- 2013/01/23 06:00 [medline]
AID - 00003226-201211001-00008 [pii]
AID - 10.1097/ICO.0b013e31826a04dd [doi]
PST - ppublish
SO  - Cornea. 2012 Nov;31 Suppl 1:S41-4. doi: 10.1097/ICO.0b013e31826a04dd.