PMID- 23039889
OWN - NLM
STAT- MEDLINE
DCOM- 20130318
LR  - 20220311
IS  - 1365-2249 (Electronic)
IS  - 0009-9104 (Print)
IS  - 0009-9104 (Linking)
VI  - 170
IP  - 2
DP  - 2012 Nov
TI  - Normal ageing is associated with an increase in Th2 cells, MCP-1 (CCL1) and 
      RANTES (CCL5), with differences in sCD40L and PDGF-AA between sexes.
PG  - 186-93
LID - 10.1111/j.1365-2249.2012.04644.x [doi]
AB  - We have observed T helper type 2 (Th2) polarization of systemic immunity in 
      patients with metastatic malignant melanoma. We hypothesized that similar changes 
      in systemic immunity occur with ageing and may be permissive for the development 
      of melanoma. We analysed the peripheral blood of 389 healthy blood donors. All 
      subjects were profiled for peripheral blood T cell and B cell subsets, and 58 of 
      these subjects were profiled for antigen-specific cytotoxic T cell subsets 
      [cytomegalovirus (CMV), influenza and melanoma antigen recognized by T cells 1 
      (MART-1)]. Ninety-five separate healthy subjects underwent profiling of 42 plasma 
      cytokines. Ageing was associated positively with CD4(+) CD294(+) Th2 cells, and 
      associated negatively with CD3(+) T cells, cytotoxic T cells and T helper cells. 
      Ageing was also associated negatively with CMV-, influenza- and MART-1-specific 
      naive and CD8(+) T cells. There were significant increases in plasma monocyte 
      chemotactic protein 1 (MCP-1) (CCL1) and regulated upon activation normal T cell 
      expressed and secreted (RANTES) (CCL5) with age. We observed differences in 
      cytokine profiles between males and females; specifically, women had higher 
      levels of sCD40L and PDGF-AA. In summary, we demonstrated in healthy blood donors 
      that ageing was associated with an increase in cellular Th2 bias and a decline in 
      total numbers of T cells. Additionally, there was an increase in MCP-1 and RANTES 
      with ageing. Women had higher levels of sCD40L and PDGF-AA than men.
CI  - (c) 2012 British Society for Immunology.
FAU - Mansfield, A S
AU  - Mansfield AS
AD  - Departments of Oncology Medicine, Division of Hematology Immunology Biomedical 
      Statistics and Informatics Women's Health Clinic, Division of General Internal 
      Medicine, Mayo Clinic Rochester, MN 55905, USA.
FAU - Nevala, W K
AU  - Nevala WK
FAU - Dronca, R S
AU  - Dronca RS
FAU - Leontovich, A A
AU  - Leontovich AA
FAU - Shuster, L
AU  - Shuster L
FAU - Markovic, S N
AU  - Markovic SN
LA  - eng
PT  - Journal Article
PL  - England
TA  - Clin Exp Immunol
JT  - Clinical and experimental immunology
JID - 0057202
RN  - 0 (CCL2 protein, human)
RN  - 0 (CCL5 protein, human)
RN  - 0 (CD3 Complex)
RN  - 0 (CD4 Antigens)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokine CCL5)
RN  - 0 (Cytokines)
RN  - 0 (Platelet-Derived Growth Factor)
RN  - 0 (Receptors, Immunologic)
RN  - 0 (Receptors, Prostaglandin)
RN  - 0 (platelet-derived growth factor A)
RN  - 147205-72-9 (CD40 Ligand)
RN  - XZF106QU24 (prostaglandin D2 receptor)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Aging/*immunology/metabolism
MH  - B-Lymphocyte Subsets/immunology/metabolism
MH  - CD3 Complex/immunology/metabolism
MH  - CD4 Antigens/immunology/metabolism
MH  - CD40 Ligand/immunology/*metabolism
MH  - Chemokine CCL2/immunology/*metabolism
MH  - Chemokine CCL5/immunology/*metabolism
MH  - Cytokines/immunology/metabolism
MH  - Humans
MH  - Male
MH  - Melanoma/immunology/metabolism
MH  - Middle Aged
MH  - Platelet-Derived Growth Factor/immunology/*metabolism
MH  - Receptors, Immunologic/immunology/metabolism
MH  - Receptors, Prostaglandin/immunology/metabolism
MH  - Sex Factors
MH  - T-Lymphocyte Subsets/immunology/metabolism
MH  - Th2 Cells/*immunology/metabolism
MH  - Young Adult
PMC - PMC3482365
EDAT- 2012/10/09 06:00
MHDA- 2013/03/19 06:00
PMCR- 2013/11/01
CRDT- 2012/10/09 06:00
PHST- 2012/10/09 06:00 [entrez]
PHST- 2012/10/09 06:00 [pubmed]
PHST- 2013/03/19 06:00 [medline]
PHST- 2013/11/01 00:00 [pmc-release]
AID - 10.1111/j.1365-2249.2012.04644.x [doi]
PST - ppublish
SO  - Clin Exp Immunol. 2012 Nov;170(2):186-93. doi: 10.1111/j.1365-2249.2012.04644.x.