PMID- 23039899
OWN - NLM
STAT- MEDLINE
DCOM- 20130627
LR  - 20230131
IS  - 1460-9568 (Electronic)
IS  - 0953-816X (Print)
IS  - 0953-816X (Linking)
VI  - 37
IP  - 2
DP  - 2013 Jan
TI  - Circadian genes Period 1 and Period 2 in the nucleus accumbens regulate 
      anxiety-related behavior.
PG  - 242-50
LID - 10.1111/ejn.12010 [doi]
AB  - It has been suggested for some time that circadian rhythm abnormalities underlie 
      the development of multiple psychiatric disorders. However, it is unclear how 
      disruptions in individual circadian genes might regulate mood and anxiety. Here 
      we found that mice lacking functional mPeriod 1 (mPer1) or mPeriod 2 (mPer2) 
      individually did not have consistent behavioral abnormalities in measures of 
      anxiety-related behavior. However, mice deficient in both mPer1 and mPer2 had an 
      increase in levels of anxiety-like behavior in multiple measures. Moreover, we 
      found that mPer1 and mPer2 expression was reduced in the nucleus accumbens (NAc) 
      after exposure to chronic social defeat stress, a paradigm that led to increased 
      anxiety-related behavior. Following social defeat, chronic treatment with 
      fluoxetine normalized Per gene expression towards wild-type levels. Knockdown of 
      both mPer1 and mPer2 expression via RNA interference specifically in the NAc led 
      to a similar increase in anxiety-like behavior as seen in the mutant animals. 
      Taken together, these results implicate the Per genes in the NAc in response to 
      stress and the development of anxiety.
CI  - (c) 2012 Federation of European Neuroscience Societies and Blackwell Publishing 
      Ltd.
FAU - Spencer, Sade
AU  - Spencer S
AD  - Department of Psychiatry, UT Southwestern Medical Center, Dallas, TX, USA. 
      mcclungca@upmc.edu
FAU - Falcon, Edgardo
AU  - Falcon E
FAU - Kumar, Jaswinder
AU  - Kumar J
FAU - Krishnan, Vaishnav
AU  - Krishnan V
FAU - Mukherjee, Shibani
AU  - Mukherjee S
FAU - Birnbaum, Shari G
AU  - Birnbaum SG
FAU - McClung, Colleen A
AU  - McClung CA
LA  - eng
GR  - F31 MH090683/MH/NIMH NIH HHS/United States
GR  - R01 DA023988/DA/NIDA NIH HHS/United States
GR  - R01 MH082876/MH/NIMH NIH HHS/United States
GR  - MH082876/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20121008
PL  - France
TA  - Eur J Neurosci
JT  - The European journal of neuroscience
JID - 8918110
RN  - 0 (Antidepressive Agents, Second-Generation)
RN  - 0 (Per1 protein, mouse)
RN  - 0 (Per2 protein, mouse)
RN  - 0 (Period Circadian Proteins)
RN  - 0 (RNA, Small Interfering)
RN  - 01K63SUP8D (Fluoxetine)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents, Second-Generation/pharmacology
MH  - Anxiety/*genetics/metabolism
MH  - Avoidance Learning
MH  - Fluoxetine/pharmacology
MH  - Maze Learning
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Mutant Strains
MH  - Mutation
MH  - Nucleus Accumbens/*metabolism/physiology
MH  - Period Circadian Proteins/genetics/*metabolism
MH  - RNA, Small Interfering
MH  - Stress, Psychological
MH  - Transcription, Genetic/drug effects
PMC - PMC3711746
MID - NIHMS477587
COIS- The authors declare no conflicts of interest with this article.
EDAT- 2012/10/09 06:00
MHDA- 2013/06/29 06:00
PMCR- 2014/01/01
CRDT- 2012/10/09 06:00
PHST- 2012/04/13 00:00 [received]
PHST- 2012/08/29 00:00 [revised]
PHST- 2012/09/01 00:00 [accepted]
PHST- 2012/10/09 06:00 [entrez]
PHST- 2012/10/09 06:00 [pubmed]
PHST- 2013/06/29 06:00 [medline]
PHST- 2014/01/01 00:00 [pmc-release]
AID - 10.1111/ejn.12010 [doi]
PST - ppublish
SO  - Eur J Neurosci. 2013 Jan;37(2):242-50. doi: 10.1111/ejn.12010. Epub 2012 Oct 8.