PMID- 23040111
OWN - NLM
STAT- MEDLINE
DCOM- 20130319
LR  - 20161125
IS  - 1532-8414 (Electronic)
IS  - 1071-9164 (Linking)
VI  - 18
IP  - 10
DP  - 2012 Oct
TI  - Genetic variants of the renin-angiotensin-aldosterone system and reverse 
      remodeling after cardiac resynchronization therapy.
PG  - 762-8
LID - S1071-9164(12)00806-8 [pii]
LID - 10.1016/j.cardfail.2012.07.008 [doi]
AB  - BACKGROUND: Reverse remodeling (RR) after cardiac resynchronization therapy (CRT) 
      is associated with favorable clinical outcomes in heart failure (HF). The 
      renin-angiotensin-aldosterone system (RAAS) is involved in the remodeling 
      process. METHODS AND RESULTS: We assessed the association between RR and 8 common 
      RAAS gene variants, which were determined by TaqMan assays, in 156 outpatients 
      with chronic HF. RR was defined as a >15% decrease in left ventricular end 
      systolic volume (LVESV) at 9 (interquartile range 7-12) months after CRT. We 
      matched 76 patients who did not show RR (RR-) to 80 RR+ control subjects by age, 
      sex, HF etiology, New York Heart Association (NYHA) functional class and left 
      ventricular ejection fraction (LVEF). The frequency of the minor allele of the 
      NR3C2 gene (rs5522 C/T), encoding the mineralocorticoid receptor, was higher in 
      RR- than in RR (24/126 vs 10/150; P value after false discovery rate correction: 
      <.0193). Conversely, LVESV decreased significantly less after CRT in carriers of 
      the NR3C2 minor C allele (P = .02). After adjustment for age, sex, NYHA 
      functional class, previous myocardial infarction, atrial fibrillation, and LVEF, 
      RR- remained independently associated with NR3C2 C allele carriage (odds ratio 
      3.093, 95% confidence interval 1.253-7.632). CONCLUSIONS: The association of RR- 
      after CRT with a common polymorphism in the mineralocorticoid receptor gene 
      involved in aldosterone signaling suggests a possible role for variants in RAAS 
      genes in progressive LV function decline, despite apparently effective CRT.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - De Maria, Renata
AU  - De Maria R
AD  - CNR Institute of Clinical Physiology, Cardiothoracic and Vascular Department, 
      Niguarda Ca' Granda Hospital, Milan, Italy. renata_de_maria@hotmail.com
FAU - Landolina, Maurizio
AU  - Landolina M
FAU - Gasparini, Maurizio
AU  - Gasparini M
FAU - Schmitz, Boris
AU  - Schmitz B
FAU - Campolo, Jonica
AU  - Campolo J
FAU - Parolini, Marina
AU  - Parolini M
FAU - Sanzo, Antonio
AU  - Sanzo A
FAU - Galimberti, Paola
AU  - Galimberti P
FAU - Bianchi, Michele
AU  - Bianchi M
FAU - Brand, Stefan-Martin
AU  - Brand SM
FAU - Parodi, Oberdan
AU  - Parodi O
FAU - Lunati, Maurizio
AU  - Lunati M
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20120829
PL  - United States
TA  - J Card Fail
JT  - Journal of cardiac failure
JID - 9442138
RN  - 0 (NR3C2 protein, human)
RN  - 0 (Receptors, Mineralocorticoid)
SB  - IM
MH  - Aged
MH  - *Cardiac Resynchronization Therapy
MH  - Case-Control Studies
MH  - Confidence Intervals
MH  - Female
MH  - *Genetic Variation
MH  - Heart Failure/diagnostic imaging/*genetics/therapy
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - Phenotype
MH  - Pilot Projects
MH  - Receptors, Mineralocorticoid/*genetics
MH  - Renin-Angiotensin System/*genetics
MH  - Statistics as Topic
MH  - Ultrasonography
MH  - Ventricular Remodeling/*genetics
EDAT- 2012/10/09 06:00
MHDA- 2013/03/21 06:00
CRDT- 2012/10/09 06:00
PHST- 2012/03/06 00:00 [received]
PHST- 2012/07/27 00:00 [revised]
PHST- 2012/07/31 00:00 [accepted]
PHST- 2012/10/09 06:00 [entrez]
PHST- 2012/10/09 06:00 [pubmed]
PHST- 2013/03/21 06:00 [medline]
AID - S1071-9164(12)00806-8 [pii]
AID - 10.1016/j.cardfail.2012.07.008 [doi]
PST - ppublish
SO  - J Card Fail. 2012 Oct;18(10):762-8. doi: 10.1016/j.cardfail.2012.07.008. Epub 
      2012 Aug 29.