PMID- 23040216
OWN - NLM
STAT- MEDLINE
DCOM- 20130603
LR  - 20221207
IS  - 1879-2472 (Electronic)
IS  - 0049-3848 (Linking)
VI  - 130
IP  - 5
DP  - 2012 Nov
TI  - Relationship between NADPH oxidase p22phox C242T, PARP-1 Val762Ala polymorphisms, 
      angiographically verified coronary artery disease and myocardial infarction in 
      South Indian patients with type 2 diabetes mellitus.
PG  - e259-65
LID - S0049-3848(12)00744-X [pii]
LID - 10.1016/j.thromres.2012.09.012 [doi]
AB  - INTRODUCTION: There has been compelling evidence for the role of oxidative stress 
      in the pathogenesis of cardiovascular complications in type 2 diabetes mellitus 
      (T2DM). We analyzed the association of C242T and Val762Ala polymorphisms of NADPH 
      oxidase p22phox and poly (ADP-ribose) polymerase-1 (PARP-1) genes respectively 
      with coronary artery disease (CAD) and its severity, myocardial infarction (MI) 
      and cardiovascular risk factors in T2DM patients. MATERIALS AND METHODS: We 
      screened 283 T2DM patients, inclusive of 160 with angiographically defined CAD, 
      73 with and 89 without MI and 121 T2DM individuals with no evidence of CAD for 
      the two gene polymorphisms. RESULTS: The 242T and 762Ala alleles were 
      significantly more frequent in T2DM subjects without CAD than those with CAD, 
      thereby associating them with a significant protective effect against development 
      of CAD [p=0.002 (C242T); 0.02 (Val762Ala)]. The association was further 
      characterized by a relatively lower frequency of 242T and 762Ala alleles in T2DM 
      patients with multi (MVD)/triple vessel disease respectively [p=0.003 (C242T); 
      0.02 (Val762Ala)]. Conversely, the genotype and allele frequencies of these 
      polymorphisms were not significantly different in T2DM+CAD patients with or 
      without MI. Stratification of risk by putative risk factors for CAD revealed a 
      significant interaction with these polymorphisms. Multiple logistic regression 
      analysis revealed a significant and independent association of C242T and 
      Val762Ala polymorphisms and other putative risk factors with CAD/MVD in T2DM 
      individuals. CONCLUSIONS: Our observations indicate a significant relationship 
      between p22phox C242T and PARP-1 Val762Ala polymorphisms, CAD and its severity, 
      but not with occurrence of MI in T2DM individuals with significant coronary 
      stenoses.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Narne, Parimala
AU  - Narne P
AD  - Department of Genetics, Osmania University, Hyderabad, India. 
      parimala_narne@yahoo.co.in
FAU - Ponnaluri, Kamakshi Chaithri
AU  - Ponnaluri KC
FAU - Singh, Shailender
AU  - Singh S
FAU - Siraj, Mohammed
AU  - Siraj M
FAU - Ishaq, Mohammed
AU  - Ishaq M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121002
PL  - United States
TA  - Thromb Res
JT  - Thrombosis research
JID - 0326377
RN  - EC 1.6.3.- (NADPH Oxidases)
RN  - EC 1.6.3.1 (CYBA protein, human)
RN  - EC 2.4.2.30 (PARP1 protein, human)
RN  - EC 2.4.2.30 (Poly (ADP-Ribose) Polymerase-1)
RN  - EC 2.4.2.30 (Poly(ADP-ribose) Polymerases)
SB  - IM
MH  - Angiography
MH  - Asian People
MH  - Coronary Artery Disease/diagnosis/*enzymology/genetics
MH  - Diabetes Mellitus, Type 2/*enzymology/genetics
MH  - Female
MH  - Gene Frequency
MH  - Gene Pool
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Myocardial Infarction/*enzymology/genetics
MH  - NADPH Oxidases/*genetics
MH  - Oxidative Stress/physiology
MH  - Poly (ADP-Ribose) Polymerase-1
MH  - Poly(ADP-ribose) Polymerases/*genetics
MH  - Polymorphism, Single Nucleotide
MH  - Risk Factors
EDAT- 2012/10/09 06:00
MHDA- 2013/06/05 06:00
CRDT- 2012/10/09 06:00
PHST- 2012/05/16 00:00 [received]
PHST- 2012/07/25 00:00 [revised]
PHST- 2012/09/18 00:00 [accepted]
PHST- 2012/10/09 06:00 [entrez]
PHST- 2012/10/09 06:00 [pubmed]
PHST- 2013/06/05 06:00 [medline]
AID - S0049-3848(12)00744-X [pii]
AID - 10.1016/j.thromres.2012.09.012 [doi]
PST - ppublish
SO  - Thromb Res. 2012 Nov;130(5):e259-65. doi: 10.1016/j.thromres.2012.09.012. Epub 
      2012 Oct 2.