PMID- 23040220
OWN - NLM
STAT- MEDLINE
DCOM- 20130219
LR  - 20191210
IS  - 1879-355X (Electronic)
IS  - 0360-3016 (Linking)
VI  - 85
IP  - 1
DP  - 2013 Jan 1
TI  - Dosimetric impact of using the Acuros XB algorithm for intensity modulated 
      radiation therapy and RapidArc planning in nasopharyngeal carcinomas.
PG  - e73-80
LID - S0360-3016(12)03451-7 [pii]
LID - 10.1016/j.ijrobp.2012.08.031 [doi]
AB  - PURPOSE: To assess the dosimetric implications for the intensity modulated 
      radiation therapy (IMRT) and volumetric modulated arc therapy with RapidArc (RA) 
      of nasopharyngeal carcinomas (NPC) due to the use of the Acuros XB (AXB) 
      algorithm versus the anisotropic analytical algorithm (AAA). METHODS AND 
      MATERIALS: Nine-field sliding window IMRT and triple-arc RA plans produced for 12 
      patients with NPC using AAA were recalculated using AXB. The dose distributions 
      to multiple planning target volumes (PTVs) with different prescribed doses and 
      critical organs were compared. The PTVs were separated into components in bone, 
      air, and tissue. The change of doses by AXB due to air and bone, and the 
      variation of the amount of dose changes with number of fields was also studied 
      using simple geometric phantoms. RESULTS: Using AXB instead of AAA, the averaged 
      mean dose to PTV70 (70 Gy was prescribed to PTV70) was found to be 0.9% and 1.2% 
      lower for IMRT and RA, respectively. It was approximately 1% lower in tissue, 2% 
      lower in bone, and 1% higher in air. The averaged minimum dose to PTV70 in bone 
      was approximately 4% lower for both IMRT and RA, whereas it was approximately 
      1.5% lower for PTV70 in tissue. The decrease in target doses estimated by AXB was 
      mostly contributed from the presence of bone, less from tissue, and none from 
      air. A similar trend was observed for PTV60 (60 Gy was prescribed to PTV60). The 
      doses to most serial organs were found to be 1% to 3% lower and to other organs 
      4% to 10% lower for both techniques. CONCLUSIONS: The use of the AXB algorithm is 
      highly recommended for IMRT and RapidArc planning for NPC cases.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Kan, Monica W K
AU  - Kan MW
AD  - Department of Oncology, Princess Margaret Hospital, and Department of Physics and 
      Materials Science, City University of Hong Kong, Hong Kong SAR, China. 
      kanwkm@ha.org.hk
FAU - Leung, Lucullus H T
AU  - Leung LH
FAU - Yu, Peter K N
AU  - Yu PK
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20121003
PL  - United States
TA  - Int J Radiat Oncol Biol Phys
JT  - International journal of radiation oncology, biology, physics
JID - 7603616
SB  - IM
MH  - Air
MH  - *Algorithms
MH  - Anisotropy
MH  - Bone and Bones/radiation effects
MH  - Carcinoma
MH  - Humans
MH  - Nasopharyngeal Carcinoma
MH  - Nasopharyngeal Neoplasms/diagnostic imaging/pathology/*radiotherapy
MH  - Organs at Risk/*radiation effects
MH  - Phantoms, Imaging
MH  - Radiography
MH  - Radiometry/methods
MH  - *Radiotherapy Dosage
MH  - Radiotherapy Planning, Computer-Assisted/*methods
MH  - Radiotherapy, Intensity-Modulated/*methods
MH  - Tumor Burden
EDAT- 2012/10/09 06:00
MHDA- 2013/02/21 06:00
CRDT- 2012/10/09 06:00
PHST- 2012/05/14 00:00 [received]
PHST- 2012/07/17 00:00 [revised]
PHST- 2012/08/21 00:00 [accepted]
PHST- 2012/10/09 06:00 [entrez]
PHST- 2012/10/09 06:00 [pubmed]
PHST- 2013/02/21 06:00 [medline]
AID - S0360-3016(12)03451-7 [pii]
AID - 10.1016/j.ijrobp.2012.08.031 [doi]
PST - ppublish
SO  - Int J Radiat Oncol Biol Phys. 2013 Jan 1;85(1):e73-80. doi: 
      10.1016/j.ijrobp.2012.08.031. Epub 2012 Oct 3.