PMID- 23040414
OWN - NLM
STAT- MEDLINE
DCOM- 20130603
LR  - 20131121
IS  - 1532-8600 (Electronic)
IS  - 0026-0495 (Linking)
VI  - 62
IP  - 2
DP  - 2013 Feb
TI  - Brain-derived neurotrophic factor and its relation to leptin in obese children 
      before and after weight loss.
PG  - 226-34
LID - S0026-0495(12)00287-9 [pii]
LID - 10.1016/j.metabol.2012.08.001 [doi]
AB  - OBJECTIVE: Brain-derived neurotrophic factor (BDNF) is a regulator of energy 
      homeostasis and food intake through hypothalamic signaling. Currently, data 
      regarding BDNF in children with obesity are lacking. We evaluated serum BDNF 
      concentrations in obese children, both before and after lifestyle intervention, 
      in reference to those of lean children. METHODS: A total of 90 (24 normal weight; 
      66 obese) children were studied utilizing a cross-sectional clinical outpatient 
      study design. In addition, longitudinal data analysis was performed in 30 obese 
      children participating in a lifestyle intervention for one year. RESULTS: Fasting 
      serum BDNF concentrations were higher in obese vs. normal weight children (BDNF 
      20.3+/-1.0 vs. 12.5+/-1.7 ng/mL, respectively, mean+/-SEM, p<0.001) and correlated 
      significantly to BMI standard deviation score (r=0.426, p<0.001), and leptin 
      (r=0.414, p<0.01). BDNF concentrations were not regulated in response to food, 60 
      min after ingestion of a liquid test meal. After one year lifestyle intervention, 
      delta BDNF correlated significantly to delta leptin (r=0.475, p<0.01), but not to 
      changes of insulin resistance index HOMA-IR, systolic and diastolic blood 
      pressure, HDL, LDL, and triglycerides. In a multiple stepwise linear regression 
      adjusted for pubertal stage, age, sex, and BMI, delta BDNF correlated 
      significantly (p<0.05) to delta leptin and delta triceps skinfold and in tendency 
      to delta subscapularis skinfold thickness (p=0.050). CONCLUSIONS: Our results in 
      children do not indicate a significant relationship between BDNF and insulin 
      resistance or cardiovascular risk factors. However, the correlation between 
      changes of BDNF and changes of leptin suggests a relationship between BDNF and 
      fat mass.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Roth, Christian L
AU  - Roth CL
AD  - Seattle Children's Hospital Research Institute, Seattle, WA 98101, USA. 
      christian.roth@seattlechildrens.org
FAU - Elfers, Clinton
AU  - Elfers C
FAU - Gebhardt, Ursel
AU  - Gebhardt U
FAU - Muller, Hermann L
AU  - Muller HL
FAU - Reinehr, Thomas
AU  - Reinehr T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121003
PL  - United States
TA  - Metabolism
JT  - Metabolism: clinical and experimental
JID - 0375267
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Leptin)
RN  - 0 (Triglycerides)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - Adolescent
MH  - Body Mass Index
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Child
MH  - Cholesterol/blood
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Insulin Resistance/*physiology
MH  - Leptin/*blood
MH  - Life Style
MH  - Longitudinal Studies
MH  - Male
MH  - Obesity/*blood
MH  - Triglycerides/blood
MH  - Weight Loss/physiology
EDAT- 2012/10/09 06:00
MHDA- 2013/06/05 06:00
CRDT- 2012/10/09 06:00
PHST- 2011/12/18 00:00 [received]
PHST- 2012/08/03 00:00 [revised]
PHST- 2012/08/05 00:00 [accepted]
PHST- 2012/10/09 06:00 [entrez]
PHST- 2012/10/09 06:00 [pubmed]
PHST- 2013/06/05 06:00 [medline]
AID - S0026-0495(12)00287-9 [pii]
AID - 10.1016/j.metabol.2012.08.001 [doi]
PST - ppublish
SO  - Metabolism. 2013 Feb;62(2):226-34. doi: 10.1016/j.metabol.2012.08.001. Epub 2012 
      Oct 3.