PMID- 23041279
OWN - NLM
STAT- MEDLINE
DCOM- 20131022
LR  - 20211021
IS  - 1090-2139 (Electronic)
IS  - 0889-1591 (Print)
IS  - 0889-1591 (Linking)
VI  - 30
DP  - 2013 May
TI  - Absence of CCL2 is sufficient to restore hippocampal neurogenesis following 
      cranial irradiation.
PG  - 33-44
LID - S0889-1591(12)00437-0 [pii]
LID - 10.1016/j.bbi.2012.09.010 [doi]
AB  - Cranial irradiation for the treatment of brain tumors causes a delayed and 
      progressive cognitive decline that is pronounced in young patients. Dysregulation 
      of neural stem and progenitor cells is thought to contribute to these effects by 
      altering early childhood brain development. Earlier work has shown that 
      irradiation creates a chronic neuroinflammatory state that severely and 
      selectively impairs postnatal and adult neurogenesis. Here we show that 
      irradiation induces a transient non-classical cytokine response with selective 
      upregulation of CCL2/monocyte chemoattractant protein-1 (MCP-1). Absence of CCL2 
      signaling in the hours after irradiation is alone sufficient to attenuate chronic 
      microglia activation and allow the recovery of neurogenesis in the weeks 
      following irradiation. This identifies CCL2 signaling as a potential clinical 
      target for moderating the long-term defects in neural stem cell function 
      following cranial radiation in children.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Lee, Star W
AU  - Lee SW
AD  - Stanford University, Institute for Stem Cell Biology and Regenerative Medicine, 
      Stanford, CA 94305-5454, USA.
FAU - Haditsch, Ursula
AU  - Haditsch U
FAU - Cord, Branden J
AU  - Cord BJ
FAU - Guzman, Raphael
AU  - Guzman R
FAU - Kim, Soo Jeong
AU  - Kim SJ
FAU - Boettcher, Chotima
AU  - Boettcher C
FAU - Priller, Josef
AU  - Priller J
FAU - Ormerod, Brandi K
AU  - Ormerod BK
FAU - Palmer, Theo D
AU  - Palmer TD
LA  - eng
GR  - R01NS045113-02/NS/NINDS NIH HHS/United States
GR  - T32GM0076365/GM/NIGMS NIH HHS/United States
GR  - T32 MH020016/MH/NIMH NIH HHS/United States
GR  - R01 MH085911/MH/NIMH NIH HHS/United States
GR  - F30 NS04696701/NS/NINDS NIH HHS/United States
GR  - R01 MH071472/MH/NIMH NIH HHS/United States
GR  - R01 NS045113/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20121003
PL  - Netherlands
TA  - Brain Behav Immun
JT  - Brain, behavior, and immunity
JID - 8800478
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Animals
MH  - Cells, Cultured
MH  - Chemokine CCL2/genetics/*metabolism
MH  - *Cranial Irradiation
MH  - Hippocampus/*cytology/metabolism/radiation effects
MH  - Male
MH  - Mice
MH  - Mice, Knockout
MH  - Microglia/cytology/metabolism/radiation effects
MH  - Neural Stem Cells/cytology/metabolism/radiation effects
MH  - Neurogenesis/*physiology/radiation effects
MH  - Neurons/*cytology/metabolism/radiation effects
PMC - PMC3556199
MID - NIHMS413185
EDAT- 2012/10/09 06:00
MHDA- 2013/10/23 06:00
PMCR- 2014/05/01
CRDT- 2012/10/09 06:00
PHST- 2012/07/26 00:00 [received]
PHST- 2012/09/19 00:00 [revised]
PHST- 2012/09/20 00:00 [accepted]
PHST- 2012/10/09 06:00 [entrez]
PHST- 2012/10/09 06:00 [pubmed]
PHST- 2013/10/23 06:00 [medline]
PHST- 2014/05/01 00:00 [pmc-release]
AID - S0889-1591(12)00437-0 [pii]
AID - 10.1016/j.bbi.2012.09.010 [doi]
PST - ppublish
SO  - Brain Behav Immun. 2013 May;30:33-44. doi: 10.1016/j.bbi.2012.09.010. Epub 2012 
      Oct 3.