PMID- 23041752
OWN - NLM
STAT- MEDLINE
DCOM- 20130701
LR  - 20220321
IS  - 1473-5598 (Electronic)
IS  - 0263-6352 (Linking)
VI  - 30
IP  - 12
DP  - 2012 Dec
TI  - Association of left ventricular motion and central augmentation index in healthy 
      young men.
PG  - 2395-402
LID - 10.1097/HJH.0b013e328358bee2 [doi]
AB  - BACKGROUND: Central blood pressure is a determinant of cardiovascular outcome; 
      however, it can be described by parameters other than systolic and diastolic 
      pressure with central augmentation index (AIx) often utilized. Although generally 
      considered as determined by peripheral pressure wave reflection, not all data are 
      consistent with this interpretation of AIx. We hypothesized that the motion of 
      the heart during systole may influence central pressure waveform morphology, 
      including the AIx. METHOD: We studied the carotid pressure waveform, aortic 
      stiffness and endothelial function in 20 healthy young men (full data available 
      in 19). Arterial stiffness was measured by carotid femoral pulse wave velocity 
      (cfPWV), endothelial function by peripheral arterial plethysmography (PAPl) and 
      central blood pressure waveform by carotid applanation tonometry. Basal cardiac 
      motion was assessed with pulsed wave tissue Doppler imaging of the septal mitral 
      annulus. RESULTS: Carotid AIx decreased after the administration of glyceryl 
      trinitrate by 11.3 +/- (sem) 4.6% (P = 0.02); however, time to the inflection point 
      (Ti) did not change. During systolic contraction at both baseline and after 
      glyceryl trinitrate, time to peak annular systolic velocity was directly related 
      to, and always preceded, carotid Ti (R(2) = 0.81; P < 0.01). Carotid Ti and AIx 
      were not related to cfPWV or endothelial function. CONCLUSION: In fit young men, 
      rather than only being a consequence of arterial properties Ti, and therefore 
      central AIx, may be substantially determined by left ventricular systolic 
      function. These findings question the interpretation of central AIx as a measure 
      of pressure wave reflection and aortic stiffness and potentially impact its 
      interpretation in diagnosis and treatment of cardiovascular risk.
FAU - Cheng, Kevin
AU  - Cheng K
AD  - Monash Cardiovascular Research Centre, MonashHeart and Monash University, 
      Department of Medicine, Monash Medical Centre, Melbourne, Australia.
FAU - Cameron, James D
AU  - Cameron JD
FAU - Tung, Matthew
AU  - Tung M
FAU - Mottram, Philip M
AU  - Mottram PM
FAU - Meredith, Ian T
AU  - Meredith IT
FAU - Hope, Sarah A
AU  - Hope SA
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - J Hypertens
JT  - Journal of hypertension
JID - 8306882
SB  - IM
CIN - J Hypertens. 2012 Dec;30(12):2276-8. PMID: 23151883
CIN - J Hypertens. 2013 Apr;31(4):841-3. PMID: 23466896
CIN - J Hypertens. 2013 Apr;31(4):843. PMID: 23466897
MH  - Adult
MH  - Blood Pressure/*physiology
MH  - Carotid Arteries/physiology
MH  - Endothelium, Vascular/physiology
MH  - Humans
MH  - Male
MH  - Mitral Valve/diagnostic imaging
MH  - Pulse Wave Analysis
MH  - Systole/*physiology
MH  - Ultrasonography
MH  - Vascular Stiffness/physiology
MH  - Ventricular Function, Left/*physiology
EDAT- 2012/10/09 06:00
MHDA- 2013/07/03 06:00
CRDT- 2012/10/09 06:00
PHST- 2012/10/09 06:00 [entrez]
PHST- 2012/10/09 06:00 [pubmed]
PHST- 2013/07/03 06:00 [medline]
AID - 10.1097/HJH.0b013e328358bee2 [doi]
PST - ppublish
SO  - J Hypertens. 2012 Dec;30(12):2395-402. doi: 10.1097/HJH.0b013e328358bee2.