PMID- 23041759
OWN - NLM
STAT- MEDLINE
DCOM- 20130509
LR  - 20190412
IS  - 1873-7544 (Electronic)
IS  - 0306-4522 (Linking)
VI  - 227
DP  - 2012 Dec 27
TI  - Physical training exerts neuroprotective effects in the regulation of 
      neurochemical factors in an animal model of Parkinson's disease.
PG  - 305-12
LID - S0306-4522(12)00990-6 [pii]
LID - 10.1016/j.neuroscience.2012.09.063 [doi]
AB  - The effect of physical training on the neurochemical and oxidative stress markers 
      were evaluated in the striatum of rats with Parkinson's disease (PD). 
      Untrained+sham-operated (USO), untrained+PD (UPD), trained+sham-operated (TSO), 
      and trained+PD (TPD) were submitted to training on the treadmill. The PD was 
      induced and 7 days after the lesion, the animals underwent a rotational test and 
      euthanasia by decapitation. The striatum was homogenized for Western Blot with 
      anti-tyrosine hydroxylase (TH), anti-brain-derived neurotrophic factor (BDNF), 
      anti-alpha-synuclein, anti-sarcoplasmic reticulum Ca(2+)-ATPase (SERCA II), 
      anti-superoxide dismutase (SOD), anti-catalase (CAT), anti-glutathione peroxidase 
      (GPX), and specific buffer for oxidative damage (TBARS and carbonyl content). The 
      UPD and TPD groups showed a clear rotational asymmetry, apart from a significant 
      reduction in the level of TH, BDNF, alpha-synuclein, SOD, CAT, and GPX as well as an 
      increase in the TBARS and carbonyl content, as observed in the UPD group. The TH 
      level was not significantly altered but the TPD group increased the levels of 
      BNDF, SERCA II, SOD, and CAT and decreased the oxidative damage in lipids and 
      protein. The effects of exercise on PD indicate the possibility that exercise, to 
      a certain extent, modulates neurochemical status in the striatum of rats, 
      possibly by improving the oxidative stress parameters.
CI  - Copyright (c) 2012 IBRO. Published by Elsevier Ltd. All rights reserved.
FAU - Tuon, T
AU  - Tuon T
AD  - Laboratory of Exercise Biochemistry and Physiology, Postgraduate Program in 
      Health Sciences, Health Sciences Unit, Universidade do Extremo Sul Catarinense, 
      Criciuma, Santa Catarina, Brazil.
FAU - Valvassori, S S
AU  - Valvassori SS
FAU - Lopes-Borges, J
AU  - Lopes-Borges J
FAU - Luciano, T
AU  - Luciano T
FAU - Trom, C B
AU  - Trom CB
FAU - Silva, L A
AU  - Silva LA
FAU - Quevedo, J
AU  - Quevedo J
FAU - Souza, C T
AU  - Souza CT
FAU - Lira, F S
AU  - Lira FS
FAU - Pinho, R A
AU  - Pinho RA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121003
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Atp2a2 protein, rat)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Sympatholytics)
RN  - 0 (Thiobarbituric Acid Reactive Substances)
RN  - 0 (alpha-Synuclein)
RN  - 8HW4YBZ748 (Oxidopamine)
RN  - EC 1.14.16.2 (Tyrosine 3-Monooxygenase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - EC 3.6.3.8 (Sarcoplasmic Reticulum Calcium-Transporting ATPases)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Corpus Striatum/*metabolism
MH  - Disease Models, Animal
MH  - Male
MH  - Motor Activity/drug effects/physiology
MH  - Oxidopamine/toxicity
MH  - Parkinson Disease/etiology/*metabolism/pathology/*rehabilitation
MH  - *Physical Conditioning, Animal
MH  - Rats
MH  - Rats, Wistar
MH  - Rotarod Performance Test
MH  - Sarcoplasmic Reticulum Calcium-Transporting ATPases/metabolism
MH  - Superoxide Dismutase/metabolism
MH  - Sympatholytics/toxicity
MH  - Thiobarbituric Acid Reactive Substances/metabolism
MH  - Tyrosine 3-Monooxygenase/metabolism
MH  - alpha-Synuclein/metabolism
EDAT- 2012/10/09 06:00
MHDA- 2013/05/10 06:00
CRDT- 2012/10/09 06:00
PHST- 2012/07/06 00:00 [received]
PHST- 2012/09/23 00:00 [revised]
PHST- 2012/09/24 00:00 [accepted]
PHST- 2012/10/09 06:00 [entrez]
PHST- 2012/10/09 06:00 [pubmed]
PHST- 2013/05/10 06:00 [medline]
AID - S0306-4522(12)00990-6 [pii]
AID - 10.1016/j.neuroscience.2012.09.063 [doi]
PST - ppublish
SO  - Neuroscience. 2012 Dec 27;227:305-12. doi: 10.1016/j.neuroscience.2012.09.063. 
      Epub 2012 Oct 3.