PMID- 23042984
OWN - NLM
STAT- MEDLINE
DCOM- 20130708
LR  - 20231213
IS  - 1469-994X (Electronic)
IS  - 1462-2203 (Linking)
VI  - 15
IP  - 2
DP  - 2013 Feb
TI  - In vitro particle size distributions in electronic and conventional cigarette 
      aerosols suggest comparable deposition patterns.
PG  - 501-8
LID - 10.1093/ntr/nts165 [doi]
AB  - INTRODUCTION: Electronic cigarette users ("vapers") inhale aerosols of water, 
      nicotine, and propylene glycol (PG) or vegetable glycerin (VG). Aerosol particle 
      sizes should affect deposition patterns in vapers and bystanders. METHODS: 
      Aerosols were generated by a smoking machine and an electronic cigarette filled 
      with 16mg/ml nicotine in aqueous PG or VG solution. A scanning mobility particle 
      sizer (SMPS) counted particles of 10-1,000 nm diameters. A single puff experiment 
      counted particles immediately and after aging 10 and 40 s. A steady-state 
      experiment counted particles emitted from a collection chamber, untreated and 
      after desiccation or organic vapor removal. The International Commission on 
      Radiological Protection (ICRP) human respiratory tract model was used to estimate 
      deposition. Results were compared to similar data from reference cigarettes. 
      RESULTS: Puffs generated peak particle counts at (VG) 180 nm and (PG) 120 nm. 
      Steady-state peaks occurred around 400 nm. Organic vapor removal eliminated small 
      particles and reduced the size and number of large particles. Desiccation reduced 
      the total volume of particles by 70% (VG, small PG) to 88% (large PG). The ICRP 
      model predicted 7%-18% alveolar delivery; 9%-19% venous delivery, mostly in the 
      head; and 73%-80% losses by exhalation. Reference cigarettes generated more 
      particles initially, but were otherwise similar; however, in vivo smoke particle 
      deposition is higher than the model predicts. CONCLUSIONS: Nicotine delivery may 
      depend on vaping technique, particle evolution, and cloud effects. Predicted 10% 
      arterial and 15% venous delivery may describe bystander exposure better than 
      vapers exposure.
FAU - Zhang, Yaping
AU  - Zhang Y
AD  - School of Engineering & Applied Science, Washington University in St. Louis, St. 
      Louis, MO 633110, USA.
FAU - Sumner, Walton
AU  - Sumner W
FAU - Chen, Da-Ren
AU  - Chen DR
LA  - eng
PT  - Journal Article
DEP - 20121004
PL  - England
TA  - Nicotine Tob Res
JT  - Nicotine & tobacco research : official journal of the Society for Research on 
      Nicotine and Tobacco
JID - 9815751
RN  - 0 (Aerosols)
RN  - 6M3C89ZY6R (Nicotine)
SB  - IM
MH  - *Aerosols
MH  - Humans
MH  - In Vitro Techniques
MH  - Nicotine/*administration & dosage/pharmacokinetics
MH  - Particle Size
MH  - *Nicotiana
EDAT- 2012/10/09 06:00
MHDA- 2013/07/09 06:00
CRDT- 2012/10/09 06:00
PHST- 2012/10/09 06:00 [entrez]
PHST- 2012/10/09 06:00 [pubmed]
PHST- 2013/07/09 06:00 [medline]
AID - nts165 [pii]
AID - 10.1093/ntr/nts165 [doi]
PST - ppublish
SO  - Nicotine Tob Res. 2013 Feb;15(2):501-8. doi: 10.1093/ntr/nts165. Epub 2012 Oct 4.