PMID- 23043431
OWN - NLM
STAT- MEDLINE
DCOM- 20130308
LR  - 20211021
IS  - 1471-2202 (Electronic)
IS  - 1471-2202 (Linking)
VI  - 13
DP  - 2012 Oct 8
TI  - Effect of maternal excessive iodine intake on neurodevelopment and cognitive 
      function in rat offspring.
PG  - 121
LID - 10.1186/1471-2202-13-121 [doi]
AB  - BACKGROUND: Iodine deficiency and iodine excess are both associated with adverse 
      health consequences. Iodine deficiency during pregnancy leads to insufficient 
      maternal thyroid hormone, subsequently causing irreversible adverse effects on 
      the neurological and cognitive functions of the offspring. The results of our 
      previous epidemiological study suggested that mild iodine excess might increase 
      the prevalence of subclinical hypothyroidism. In the present study, female Wistar 
      rats maintained on low-iodine grain were randomly assigned to three groups based 
      on iodated water concentration: low iodine (LI, 1.2 mug/d), normal iodine (NI, 
      5-6 mug/d), and 3-fold high iodine (3HI, 15-16 mug/d). The present study 
      investigated whether higher-than-normal iodine intake (3HI) by rats from before 
      pregnancy until breastfeeding affects the postnatal (PN) neurodevelopment (PN7 
      and PN45) of their offspring during particularly sensitive periods in brain 
      development. RESULTS: After 12 weeks of treatment (before pregnancy), iodine 
      concentrations in urine and thyroid tissue and circulating thyroxine of adult 
      females correlated with iodine intake. Brain-derived neurotrophic factor (BDNF) 
      expression in the hippocampi of pups on PN7 and PN45 was decreased in 3HI group 
      compared to the NI controls (P < 0.05, all) On PN7 and PN45, the BDNF levels of 
      the 3HI pups were 83.5% and 88.8%, respectively, that of the NI pups. In 
      addition, the 3HI group had a higher neuroendocrine-specific protein A (NSP-A) 
      level than the NI controls on PN7 (P < 0.05). NSP-A levels of the 3HI pups were 
      117.0% that of the NI pups. No significant difference was observed in the 
      expressions of c-Fos or c-Jun in the hippocampal CA1 region of the 3HI group 
      compared to the controls (P > 0.05). Results from the Morris water maze test 
      revealed that pups of the 3HI group had mild learning and spatial memory 
      deficits. CONCLUSIONS: The neurodevelopmental and cognitive deficits of the 3HI 
      pups were mild and temporary, likely related to the changes in hippocampal 
      protein expressions of BDNF and NSP-A.
FAU - Zhang, Le
AU  - Zhang L
AD  - Department of Endocrinology and Metabolism, First Affiliated Hospital of China 
      Medical University, Shenyang 110001, People's Republic of China.
FAU - Teng, Weiping
AU  - Teng W
FAU - Liu, Yuhui
AU  - Liu Y
FAU - Li, Jing
AU  - Li J
FAU - Mao, Jinyuan
AU  - Mao J
FAU - Fan, Chenling
AU  - Fan C
FAU - Wang, Hong
AU  - Wang H
FAU - Zhang, Hongmei
AU  - Zhang H
FAU - Shan, Zhongyan
AU  - Shan Z
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121008
PL  - England
TA  - BMC Neurosci
JT  - BMC neuroscience
JID - 100966986
RN  - 0 (Anti-Infective Agents, Local)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 9002-71-5 (Thyrotropin)
RN  - 9679TC07X4 (Iodine)
RN  - Q51BO43MG4 (Thyroxine)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Animals, Newborn
MH  - Anti-Infective Agents, Local/*adverse effects
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Cognition Disorders/*etiology
MH  - Developmental Disabilities/*etiology
MH  - Female
MH  - Iodine/*adverse effects/metabolism/urine
MH  - Male
MH  - Maze Learning
MH  - Nervous System Diseases/*etiology
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/*chemically induced/metabolism/*physiopathology
MH  - Rats
MH  - Rats, Wistar
MH  - Thyroid Gland/metabolism
MH  - Thyrotropin/blood
MH  - Thyroxine/blood
PMC - PMC3479063
EDAT- 2012/10/10 06:00
MHDA- 2013/03/09 06:00
PMCR- 2012/10/08
CRDT- 2012/10/10 06:00
PHST- 2012/05/21 00:00 [received]
PHST- 2012/10/04 00:00 [accepted]
PHST- 2012/10/10 06:00 [entrez]
PHST- 2012/10/10 06:00 [pubmed]
PHST- 2013/03/09 06:00 [medline]
PHST- 2012/10/08 00:00 [pmc-release]
AID - 1471-2202-13-121 [pii]
AID - 10.1186/1471-2202-13-121 [doi]
PST - epublish
SO  - BMC Neurosci. 2012 Oct 8;13:121. doi: 10.1186/1471-2202-13-121.