PMID- 23043631
OWN - NLM
STAT- MEDLINE
DCOM- 20130716
LR  - 20211021
IS  - 1476-5381 (Electronic)
IS  - 0007-1188 (Print)
IS  - 0007-1188 (Linking)
VI  - 168
IP  - 4
DP  - 2013 Feb
TI  - Differential effects of cathinone compounds and MDMA on body temperature in the 
      rat, and pharmacological characterization of mephedrone-induced hypothermia.
PG  - 966-77
LID - 10.1111/j.1476-5381.2012.02236.x [doi]
AB  - BACKGROUND AND PURPOSE: Recreational users report that mephedrone has similar 
      psychoactive effects to 3,4-methylenedioxymethamphetamine (MDMA). MDMA induces 
      well-characterized changes in body temperature due to complex monoaminergic 
      effects on central thermoregulation, peripheral blood flow and thermogenesis, but 
      there are little preclinical data on the acute effects of mephedrone or other 
      synthetic cathinones. EXPERIMENTAL APPROACH: The acute effects of cathinone, 
      methcathinone and mephedrone on rectal and tail temperature were examined in 
      individually housed rats, with MDMA included for comparison. Rats were killed 2 h 
      post-injection and brain regions were collected for quantification of 5-HT, 
      dopamine and major metabolites. Further studies examined the impact of selected 
      alpha-adrenoceptor and dopamine receptor antagonists on mephedrone-induced changes in 
      rectal temperature and plasma catecholamines. KEY RESULTS: At normal room 
      temperature, MDMA caused sustained decreases in rectal and tail temperature. 
      Mephedrone caused a transient decrease in rectal temperature, which was enhanced 
      by alpha(1) -adrenoceptor and dopamine D(1) receptor blockade, and a prolonged 
      decrease in tail temperature. Cathinone and methcathinone caused sustained 
      increases in rectal temperature. MDMA decreased 5-HT and/or 5-hydroxyindoleacetic 
      acid (5-HIAA) content in several brain regions and reduced striatal homovanillic 
      acid (HVA) levels, whereas cathinone and methcathinone increased striatal HVA and 
      5-HIAA. Cathinone elevated striatal and hypothalamic 5-HT. Mephedrone elevated 
      plasma noradrenaline levels, an effect prevented by alpha-adrenoceptor and dopamine 
      receptor antagonists. CONCLUSIONS AND IMPLICATIONS: MDMA and cathinones have 
      different effects on thermoregulation, and their acute effects on brain 
      monoamines also differ. These findings suggest that the adverse effects of 
      cathinones in humans cannot be extrapolated from previous observations on MDMA.
CI  - (c) 2012 The Authors. British Journal of Pharmacology (c) 2012 The British 
      Pharmacological Society.
FAU - Shortall, S E
AU  - Shortall SE
AD  - School of Biomedical Sciences, University of Nottingham Medical School, Queen's 
      Medical Centre, Nottingham, UK.
FAU - Green, A R
AU  - Green AR
FAU - Swift, K M
AU  - Swift KM
FAU - Fone, K C F
AU  - Fone KC
FAU - King, M V
AU  - King MV
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Br J Pharmacol
JT  - British journal of pharmacology
JID - 7502536
RN  - 0 (Adrenergic Antagonists)
RN  - 0 (Alkaloids)
RN  - 0 (Catecholamines)
RN  - 0 (Dopamine Antagonists)
RN  - 44RAL3456C (Methamphetamine)
RN  - 540EI4406J (cathinone)
RN  - 8BA8T27317 (mephedrone)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Adrenergic Antagonists/pharmacology
MH  - Alkaloids/*pharmacology
MH  - Animals
MH  - Body Temperature/drug effects
MH  - Body Temperature Regulation/*drug effects
MH  - Brain/drug effects/metabolism
MH  - Catecholamines/blood/metabolism
MH  - Dopamine Antagonists/pharmacology
MH  - Hypothermia/*chemically induced/physiopathology
MH  - Male
MH  - Methamphetamine/*analogs & derivatives/pharmacology
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Regional Blood Flow/drug effects
PMC - PMC3631384
EDAT- 2012/10/10 06:00
MHDA- 2013/07/17 06:00
PMCR- 2014/02/01
CRDT- 2012/10/10 06:00
PHST- 2012/04/02 00:00 [received]
PHST- 2012/08/31 00:00 [revised]
PHST- 2012/09/09 00:00 [accepted]
PHST- 2012/10/10 06:00 [entrez]
PHST- 2012/10/10 06:00 [pubmed]
PHST- 2013/07/17 06:00 [medline]
PHST- 2014/02/01 00:00 [pmc-release]
AID - 10.1111/j.1476-5381.2012.02236.x [doi]
PST - ppublish
SO  - Br J Pharmacol. 2013 Feb;168(4):966-77. doi: 10.1111/j.1476-5381.2012.02236.x.