PMID- 23043872
OWN - NLM
STAT- MEDLINE
DCOM- 20130507
LR  - 20220310
IS  - 1573-2509 (Electronic)
IS  - 0920-9964 (Print)
IS  - 0920-9964 (Linking)
VI  - 142
IP  - 1-3
DP  - 2012 Dec
TI  - North American Prodrome Longitudinal Study (NAPLS 2): overview and recruitment.
PG  - 77-82
LID - S0920-9964(12)00535-X [pii]
LID - 10.1016/j.schres.2012.09.012 [doi]
AB  - The North American Prodrome Longitudinal Study (NAPLS) is a consortium of eight 
      programs focusing on the psychosis prodrome. Funded by the National Institute of 
      Mental Health (NIMH), the sites are located at Emory University, Harvard 
      University, University of Calgary, UCLA, UCSD, University of North Carolina 
      Chapel Hill, Yale University, and Zucker Hillside Hospital. Although the programs 
      initially developed independently, they previously collaborated to combine their 
      historical datasets and to produce a series of analyses on predictors of 
      psychosis in one of the largest samples of longitudinally followed prodromal 
      subjects worldwide. This led to the development of a five year prospective study 
      "Predictors and Mechanisms of Conversion to Psychosis", (also known as NAPLS-2) 
      with three major aims: (1) to prospectively test the prediction algorithm 
      developed in NAPLS-1, (2) to investigate the neuroanatomical, neurophysiological, 
      neurocognitive, and neurohormonal factors that may contribute to the development 
      of psychosis, and (3) to develop a repository of DNA, RNA, and plasma from 
      participants meeting diagnostic criteria for a clinical high risk (CHR) state and 
      from demographically similar healthy subjects. Funded by NIMH in 2008, NAPLS-2 
      will generate the largest CHR for psychosis sample with 720 CHR and 240 healthy 
      comparison subjects, and thus will provide statistical power and scientific scope 
      that cannot be duplicated by any single site study. This paper describes the 
      overall methodology of the NAPLS-2 project and reports on the ascertainment and 
      demographics at the midway point of the study with (360 CHR) and 180 controls.
CI  - Copyright (c) 2012 Elsevier B.V. All rights reserved.
FAU - Addington, Jean
AU  - Addington J
AD  - Department of Psychiatry, University of Calgary, Calgary, Alberta, Canada. 
      jmadding@ucalgary.ca
FAU - Cadenhead, Kristin S
AU  - Cadenhead KS
FAU - Cornblatt, Barbara A
AU  - Cornblatt BA
FAU - Mathalon, Daniel H
AU  - Mathalon DH
FAU - McGlashan, Thomas H
AU  - McGlashan TH
FAU - Perkins, Diana O
AU  - Perkins DO
FAU - Seidman, Larry J
AU  - Seidman LJ
FAU - Tsuang, Ming T
AU  - Tsuang MT
FAU - Walker, Elaine F
AU  - Walker EF
FAU - Woods, Scott W
AU  - Woods SW
FAU - Addington, Jack A
AU  - Addington JA
FAU - Cannon, Tyrone D
AU  - Cannon TD
LA  - eng
GR  - U01MH082004-01A1/MH/NIMH NIH HHS/United States
GR  - P50 MH080272/MH/NIMH NIH HHS/United States
GR  - U01MH082022/MH/NIMH NIH HHS/United States
GR  - U01 MH081988/MH/NIMH NIH HHS/United States
GR  - U01MH081988/MH/NIMH NIH HHS/United States
GR  - U01 MH076989/MH/NIMH NIH HHS/United States
GR  - K24 MH076191/MH/NIMH NIH HHS/United States
GR  - U01 MH081857-05/MH/NIMH NIH HHS/United States
GR  - U01MH081984/MH/NIMH NIH HHS/United States
GR  - MH081902/MH/NIMH NIH HHS/United States
GR  - K24 MH76191/MH/NIMH NIH HHS/United States
GR  - U01 MH082022/MH/NIMH NIH HHS/United States
GR  - U01 MH081984/MH/NIMH NIH HHS/United States
GR  - R01 MH60720/MH/NIMH NIH HHS/United States
GR  - R01 MH060720/MH/NIMH NIH HHS/United States
GR  - U01 MH081928/MH/NIMH NIH HHS/United States
GR  - U01 MH081857/MH/NIMH NIH HHS/United States
GR  - U01 MH082004/MH/NIMH NIH HHS/United States
GR  - U01 MH081944/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20121006
PL  - Netherlands
TA  - Schizophr Res
JT  - Schizophrenia research
JID - 8804207
SB  - IM
MH  - *Biomedical Research
MH  - Cooperative Behavior
MH  - Female
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Neuropsychological Tests
MH  - North America
MH  - *Patient Selection
MH  - Referral and Consultation
MH  - Schizophrenia/*diagnosis/*therapy
MH  - Schizophrenic Psychology
PMC - PMC3502644
MID - NIHMS411004
COIS- Conflict of interest There are no conflicts of interest for any of the authors 
      with respect to the data in this paper or for the study.
EDAT- 2012/10/10 06:00
MHDA- 2013/05/08 06:00
PMCR- 2013/12/01
CRDT- 2012/10/10 06:00
PHST- 2012/06/01 00:00 [received]
PHST- 2012/09/12 00:00 [revised]
PHST- 2012/09/17 00:00 [accepted]
PHST- 2012/10/10 06:00 [entrez]
PHST- 2012/10/10 06:00 [pubmed]
PHST- 2013/05/08 06:00 [medline]
PHST- 2013/12/01 00:00 [pmc-release]
AID - S0920-9964(12)00535-X [pii]
AID - 10.1016/j.schres.2012.09.012 [doi]
PST - ppublish
SO  - Schizophr Res. 2012 Dec;142(1-3):77-82. doi: 10.1016/j.schres.2012.09.012. Epub 
      2012 Oct 6.