PMID- 23044304
OWN - NLM
STAT- MEDLINE
DCOM- 20130308
LR  - 20121009
IS  - 2542-5641 (Electronic)
IS  - 0366-6999 (Linking)
VI  - 125
IP  - 19
DP  - 2012 Oct
TI  - Vasculogenic mimicry is a key prognostic factor for laryngeal squamous cell 
      carcinoma: a new pattern of blood supply.
PG  - 3445-9
AB  - BACKGROUND: Recurrence and local lymph node metastasis affected the prognosis of 
      patients with laryngeal cancer. The aim of this study was to analyze clinical and 
      pathological significance of vasculogenic mimicry (VM) in laryngeal squamous cell 
      carcinoma (LSCC) and evaluate its contribution to prognosis. METHODS: Data of 168 
      cases of LSCC were reviewed retrospectively to reveal clinical pathology and 
      prognostic significance of VM. CD31 and periodic acid-Schiff double staining was 
      used to identify VM. RESULTS: VM in LSCC contributed to lymph node metastasis (P 
      = 0.003) and clinical progression. VM correlated to histopathology grade (P = 
      0.001) of LSCC. VM was an adverse prognostic factor for both disease-specific 
      survival (P = 0.039) and metastasis-free survival (P = 0.042) by univariate 
      survival analyses. And it was an independent prognostic factor for only 
      disease-specific survival (P = 0.003) by multivariate survival analyses. 
      CONCLUSIONS: VM existed in LSCC. LSCC with VM has more potential to invasion and 
      metastasis.
FAU - Lin, Peng
AU  - Lin P
AD  - Department of Otolaryngology Head and Neck, Tianjin First Central Hospital, 
      Tianjin Institute of Otolaryngology, Tianjin Medical University, Tianjin 300192, 
      China. linpengf@sina.com
FAU - Wang, Wei
AU  - Wang W
FAU - Sun, Bao-Cun
AU  - Sun BC
FAU - Cai, Wen-Juan
AU  - Cai WJ
FAU - Li, Li
AU  - Li L
FAU - Lu, Hong-Hua
AU  - Lu HH
FAU - Han, Chun-Rong
AU  - Han CR
FAU - Zhang, Jin-Mei
AU  - Zhang JM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Chin Med J (Engl)
JT  - Chinese medical journal
JID - 7513795
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinoma, Squamous Cell/*pathology
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Laryngeal Neoplasms/*pathology
MH  - Lymphatic Metastasis/pathology
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Prognosis
MH  - Retrospective Studies
EDAT- 2012/10/10 06:00
MHDA- 2013/03/09 06:00
CRDT- 2012/10/10 06:00
PHST- 2012/10/10 06:00 [entrez]
PHST- 2012/10/10 06:00 [pubmed]
PHST- 2013/03/09 06:00 [medline]
PST - ppublish
SO  - Chin Med J (Engl). 2012 Oct;125(19):3445-9.