PMID- 23044395
OWN - NLM
STAT- MEDLINE
DCOM- 20140123
LR  - 20211021
IS  - 1555-3892 (Electronic)
IS  - 0963-6897 (Linking)
VI  - 22
IP  - 4
DP  - 2013
TI  - Stem cell-based therapy for ischemic heart disease.
PG  - 663-75
LID - 10.3727/096368912X655109 [doi]
AB  - Despite great advances in therapy over the past decades, ischemic heart disease 
      (IHD) remains the leading cause of death worldwide because the decrease in 
      mortality after acute myocardial infarction (AMI) leads to a longer life span in 
      patients with chronic postinfarct heart failure (HF). There are no existing 
      medical treatments that can cure chronic HF and the only currently available 
      therapeutic option for end-stage HF is heart transplantation. However, 
      transplantation is limited by the shortage of donor organs and patients require 
      lifelong immunosuppression. In the past 10 years, stem cell-based cardiac therapy 
      has been proposed as a promising approach for the treatment of IHD. There is a 
      variety of potential stem cell types for cardiac repair and regeneration, 
      including bone marrow cells (BMCs), resident cardiac stem cells (CSCs) and 
      induced pluripotent stem cells (iPSCs). Stem cell-based therapy may comprise cell 
      transplantation or cardiac tissue engineering (CTE), which might be an attractive 
      alternative to solve the problems of low retention and poor survival of 
      transplanted cells. This review focuses on the characteristics of stem cells from 
      various sources and discusses the strategies of stem cell-based therapy for the 
      treatment of IHD.
FAU - Hsiao, Lien-Cheng
AU  - Hsiao LC
AD  - Cardiac Metabolism Research Group, Department of Physiology, Anatomy and 
      Genetics, University of Oxford, Oxford, UK. lienchenghsiao@gmail.com
FAU - Carr, Carolyn
AU  - Carr C
FAU - Chang, Kuan-Cheng
AU  - Chang KC
FAU - Lin, Shinn-Zong
AU  - Lin SZ
FAU - Clarke, Kieran
AU  - Clarke K
LA  - eng
GR  - PS/02/002/14893/BHF_/British Heart Foundation/United Kingdom
GR  - RG/07/004/22659/BHF_/British Heart Foundation/United Kingdom
GR  - PG/07/059/23259/BHF_/British Heart Foundation/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20121004
PL  - United States
TA  - Cell Transplant
JT  - Cell transplantation
JID - 9208854
SB  - IM
MH  - Animals
MH  - Humans
MH  - Myocardial Ischemia/*therapy
MH  - *Stem Cell Transplantation
MH  - Stem Cells/*cytology
MH  - Tissue Engineering
EDAT- 2012/10/10 06:00
MHDA- 2014/01/24 06:00
CRDT- 2012/10/10 06:00
PHST- 2012/10/10 06:00 [entrez]
PHST- 2012/10/10 06:00 [pubmed]
PHST- 2014/01/24 06:00 [medline]
AID - ct2428hsiao [pii]
AID - 10.3727/096368912X655109 [doi]
PST - ppublish
SO  - Cell Transplant. 2013;22(4):663-75. doi: 10.3727/096368912X655109. Epub 2012 Oct 
      4.