PMID- 23044720
OWN - NLM
STAT- MEDLINE
DCOM- 20130530
LR  - 20171116
IS  - 1098-1136 (Electronic)
IS  - 0894-1491 (Linking)
VI  - 61
IP  - 2
DP  - 2013 Feb
TI  - Heterosynaptic long-term depression mediated by ATP released from astrocytes.
PG  - 178-91
LID - 10.1002/glia.22425 [doi]
AB  - Heterosynaptic long-term depression (hLTD) at untetanized synapses accompanying 
      the induction of long-term potentiation (LTP) spatially sharpens the 
      activity-induced synaptic potentiation; however, the underlying mechanism remains 
      unclear. We found that hLTD in the hippocampal CA1 region is caused by 
      stimulation-induced ATP release from astrocytes that suppresses transmitter 
      release from untetanized synaptic terminals via activation of P2Y receptors. 
      Selective stimulation of astrocytes expressing channelrhodopsin-2, a light-gated 
      cation channel permeable to Ca(2+) , resulted in LTD of synapses on neighboring 
      neurons. This synaptic modification required Ca(2+) elevation in astrocytes and 
      activation of P2Y receptors, but not N-methyl-D-aspartate receptors. Furthermore, 
      blocking P2Y receptors or buffering astrocyte intracellular Ca(2+) at a low level 
      prevented hLTD without affecting LTP induced by SC stimulation. Thus, astrocyte 
      activation is both necessary and sufficient for mediating hLTD accompanying LTP 
      induction, strongly supporting the notion that astrocytes actively participate in 
      activity-dependent synaptic plasticity of neural circuits.
CI  - Copyright (c) 2012 Wiley Periodicals, Inc.
FAU - Chen, Jiadong
AU  - Chen J
AD  - Institute of Neuroscience and Key Laboratory of Neuroscience, Shanghai Institutes 
      for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
FAU - Tan, Zhibing
AU  - Tan Z
FAU - Zeng, Li
AU  - Zeng L
FAU - Zhang, Xiaoxing
AU  - Zhang X
FAU - He, You
AU  - He Y
FAU - Gao, Wei
AU  - Gao W
FAU - Wu, Xiumei
AU  - Wu X
FAU - Li, Yuju
AU  - Li Y
FAU - Bu, Bitao
AU  - Bu B
FAU - Wang, Wei
AU  - Wang W
FAU - Duan, Shumin
AU  - Duan S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121008
PL  - United States
TA  - Glia
JT  - Glia
JID - 8806785
RN  - 0 (Antigens)
RN  - 0 (Channelrhodopsins)
RN  - 0 (Glial Fibrillary Acidic Protein)
RN  - 0 (N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate)
RN  - 0 (Proteoglycans)
RN  - 0 (Purinergic P1 Receptor Antagonists)
RN  - 0 (Purinergic P2Y Receptor Antagonists)
RN  - 0 (chondroitin sulfate proteoglycan 4)
RN  - 147336-22-9 (Green Fluorescent Proteins)
RN  - 35873-49-5 (8-cyclopentyl-1,3-dimethylxanthine)
RN  - 452VLY9402 (Serine)
RN  - 61D2G4IYVH (Adenosine Diphosphate)
RN  - 8L70Q75FXE (Adenosine Triphosphate)
RN  - C137DTR5RG (Theophylline)
RN  - K72T3FS567 (Adenosine)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Adenosine/pharmacology
MH  - Adenosine Diphosphate/analogs & derivatives/pharmacology
MH  - Adenosine Triphosphate/*metabolism/*pharmacology
MH  - Animals
MH  - Antigens/metabolism
MH  - Astrocytes/*chemistry/metabolism
MH  - Biophysics
MH  - Calcium/metabolism
MH  - Calcium Signaling/physiology
MH  - Cells, Cultured
MH  - Channelrhodopsins
MH  - Electric Stimulation
MH  - Embryo, Mammalian
MH  - Excitatory Postsynaptic Potentials/drug effects/physiology
MH  - Genetic Vectors/physiology
MH  - Glial Fibrillary Acidic Protein/genetics/metabolism
MH  - Green Fluorescent Proteins/genetics
MH  - Hippocampus/cytology
MH  - In Vitro Techniques
MH  - Long-Term Synaptic Depression/*drug effects
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Neurons/drug effects/physiology
MH  - Optical Phenomena
MH  - Patch-Clamp Techniques
MH  - Proteoglycans/metabolism
MH  - Purinergic P1 Receptor Antagonists/pharmacology
MH  - Purinergic P2Y Receptor Antagonists/pharmacology
MH  - Rats
MH  - Serine/pharmacology
MH  - Theophylline/analogs & derivatives/pharmacology
MH  - Time Factors
MH  - Transfection
EDAT- 2012/10/10 06:00
MHDA- 2013/06/01 06:00
CRDT- 2012/10/10 06:00
PHST- 2012/04/02 00:00 [received]
PHST- 2012/08/30 00:00 [accepted]
PHST- 2012/10/10 06:00 [entrez]
PHST- 2012/10/10 06:00 [pubmed]
PHST- 2013/06/01 06:00 [medline]
AID - 10.1002/glia.22425 [doi]
PST - ppublish
SO  - Glia. 2013 Feb;61(2):178-91. doi: 10.1002/glia.22425. Epub 2012 Oct 8.