PMID- 23045265
OWN - NLM
STAT- MEDLINE
DCOM- 20160316
LR  - 20211021
IS  - 1759-4820 (Electronic)
IS  - 1759-4812 (Linking)
VI  - 9
IP  - 11
DP  - 2012 Nov
TI  - Neurotrophins as regulators of urinary bladder function.
PG  - 628-37
LID - 10.1038/nrurol.2012.178 [doi]
AB  - Increased voiding frequency and urgency are among the most prevalent storage 
      lower urinary tract symptoms (LUTS), often diagnosed as part of overactive 
      bladder syndrome (OAB). It has been suggested that these symptoms are caused by 
      excessive sensory activation of the neural micturition circuit. It seems likely 
      that sensory pathway remodelling is also responsible for pain perception upon 
      bladder filling in patients with bladder pain syndrome (BPS). 
      Neurotrophins-including nerve growth factor (NGF), brain-derived nerve factor 
      (BDNF), neurotrophin-3 (NT-3) and neurotrophin-4 (NT-4)-represent master 
      modulators of neural plasticity, both in peripheral and central nervous systems. 
      Accumulating evidence points towards a role for neurotrophins in the control of 
      neural sensory function during micturition and indicates their involvement in the 
      emergence of OAB-related and BPS-related LUTS. Neurotrophins could potentially be 
      used as urinary biomarkers to improve diagnostic accuracy for OAB and BPS and 
      monitor therapy effectiveness. Proof-of-principle clinical evidence has confirmed 
      that NGF is a potential target for treating human bladder overactivity.
FAU - Ochodnicky, Peter
AU  - Ochodnicky P
AD  - Department of Pharmacology and Pharmacotherapy, Academic Medical Center, 
      University of Amsterdam, Amsterdam, The Netherlands. p.ochodnicky@amc.uva.nl
FAU - Cruz, Celia D
AU  - Cruz CD
FAU - Yoshimura, Naoki
AU  - Yoshimura N
FAU - Cruz, Francisco
AU  - Cruz F
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20121009
PL  - England
TA  - Nat Rev Urol
JT  - Nature reviews. Urology
JID - 101500082
RN  - 0 (Biomarkers)
RN  - 0 (Nerve Growth Factors)
SB  - IM
MH  - Biomarkers/urine
MH  - Cystitis, Interstitial/diagnosis/metabolism/physiopathology
MH  - Humans
MH  - Lower Urinary Tract Symptoms/metabolism/*physiopathology
MH  - Nerve Growth Factors/*physiology/urine
MH  - Urinary Bladder/metabolism/physiology/*physiopathology
MH  - Urinary Bladder, Overactive/diagnosis/metabolism/physiopathology
MH  - Urination/*physiology
EDAT- 2012/10/10 06:00
MHDA- 2016/03/17 06:00
CRDT- 2012/10/10 06:00
PHST- 2012/10/10 06:00 [entrez]
PHST- 2012/10/10 06:00 [pubmed]
PHST- 2016/03/17 06:00 [medline]
AID - nrurol.2012.178 [pii]
AID - 10.1038/nrurol.2012.178 [doi]
PST - ppublish
SO  - Nat Rev Urol. 2012 Nov;9(11):628-37. doi: 10.1038/nrurol.2012.178. Epub 2012 Oct 
      9.