PMID- 23046078
OWN - NLM
STAT- MEDLINE
DCOM- 20131028
LR  - 20220311
IS  - 1365-2265 (Electronic)
IS  - 0300-0664 (Linking)
VI  - 78
IP  - 6
DP  - 2013 Jun
TI  - Diabetes and cardiovascular events in women with polycystic ovary syndrome: a 
      20-year retrospective cohort study.
PG  - 926-34
LID - 10.1111/cen.12068 [doi]
AB  - OBJECTIVE: Women with polycystic ovary syndrome (PCOS) are potentially at 
      increased risk of cardiovascular (CV) diseases due to well-established risk 
      factors, including insulin resistance, obesity and type 2 diabetes mellitus 
      (T2DM). However, data showing excess CV events in this population are still 
      lacking. We investigated the incidence and prevalence of CV events in a cohort of 
      women with PCOS. DESIGN: Retrospective cohort study (total follow-up >12,000 
      person-years). SETTING: Leicester, Leicestershire and Rutland (Total Female 
      population of 434,859), UK. PARTICIPANTS: Two thousand three hundred and one 
      women with PCOS (mean age = 29.6 years) attending a speciality clinic in 
      Leicestershire, UK. MAIN OUTCOMES MEASURES: T2DM, myocardial infarction (MI), 
      angina, heart failure (HF), stroke and CV-related death. RESULTS: Incidence of 
      T2DM, MI, angina, HF, stroke and CV death was respectively 3.6, 0.8, 1.0, 0.3, 
      0.0 and 0.4 per 1000 person-years. At the end of follow-up, the prevalence of MI 
      in the age groups 45-54, 55-64 and >65 years was 1.9%, 6.0% and 27.3% and of 
      angina was 2.6%, 6.0% and 27.3%, respectively. Age-group-specific odds ratios for 
      the prevalence of MI and angina compared to the local female population ranged 
      between 2.6 (95% CI: 1.0-6.3) and 12.9 (CI: 3.4-48.6) with the highest ratio 
      being for MI in the group >65 years old. Age, history of hypertension and smoking 
      had significant correlations with CV outcomes in the PCOS patients. CONCLUSION: 
      We have shown a high incidence and age-group-specific prevalence of T2DM, MI and 
      angina in the women with PCOS, with over a quarter having had MI or angina in 
      those >65 years. These findings should be considered in the treatment strategies 
      and long-term planning for women with PCOS.
CI  - (c) 2012 John Wiley & Sons Ltd.
FAU - Mani, Hamidreza
AU  - Mani H
AD  - Department of Cardiovascular Sciences, Leicester Diabetes Centre, University of 
      Leicester, Leicester General Hospital, Leicester, UK. 
      hamidreza.mani@uhl-tr.nhs.uk
FAU - Levy, Miles J
AU  - Levy MJ
FAU - Davies, Melanie J
AU  - Davies MJ
FAU - Morris, Danielle H
AU  - Morris DH
FAU - Gray, Laura J
AU  - Gray LJ
FAU - Bankart, John
AU  - Bankart J
FAU - Blackledge, Hannah
AU  - Blackledge H
FAU - Khunti, Kamlesh
AU  - Khunti K
FAU - Howlett, Trevor A
AU  - Howlett TA
LA  - eng
GR  - RP-DG-1210-10183/DH_/Department of Health/United Kingdom
GR  - RP-PG-0606-1272/DH_/Department of Health/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130406
PL  - England
TA  - Clin Endocrinol (Oxf)
JT  - Clinical endocrinology
JID - 0346653
SB  - IM
CIN - Clin Endocrinol (Oxf). 2013 Jun;78(6):823-4. PMID: 23362921
MH  - Adult
MH  - Angina Pectoris/epidemiology
MH  - Cardiovascular Diseases/*epidemiology/etiology
MH  - Cohort Studies
MH  - Diabetes Mellitus, Type 2/*epidemiology
MH  - Female
MH  - Heart Failure/epidemiology
MH  - Humans
MH  - Incidence
MH  - Middle Aged
MH  - Myocardial Infarction/epidemiology
MH  - Polycystic Ovary Syndrome/*complications/epidemiology
MH  - Prevalence
MH  - Retrospective Studies
MH  - Stroke/epidemiology
MH  - United Kingdom/epidemiology
EDAT- 2012/10/11 06:00
MHDA- 2013/10/29 06:00
CRDT- 2012/10/11 06:00
PHST- 2012/07/13 00:00 [received]
PHST- 2012/08/16 00:00 [revised]
PHST- 2012/09/13 00:00 [revised]
PHST- 2012/10/04 00:00 [accepted]
PHST- 2012/10/11 06:00 [entrez]
PHST- 2012/10/11 06:00 [pubmed]
PHST- 2013/10/29 06:00 [medline]
AID - 10.1111/cen.12068 [doi]
PST - ppublish
SO  - Clin Endocrinol (Oxf). 2013 Jun;78(6):926-34. doi: 10.1111/cen.12068. Epub 2013 
      Apr 6.