PMID- 23047839
OWN - NLM
STAT- MEDLINE
DCOM- 20130212
LR  - 20220311
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 266
IP  - 1
DP  - 2013 Jan
TI  - Brain dysfunction primarily related to previous overt hepatic encephalopathy 
      compared with minimal hepatic encephalopathy: resting-state functional MR imaging 
      demonstration.
PG  - 261-70
LID - 10.1148/radiol.12120026 [doi]
AB  - PURPOSE: To investigate whether resting-state brain functional connectivity (FC) 
      differed among cirrhotic patients without overt hepatic encephalopathy (HE) 
      (OHE), those who currently had minimal HE (MHE), or those who had recovered from 
      previous OHE and to investigate whether previous bouts of OHE rather than current 
      MHE predominantly contributed to brain dysfunction in patients without current 
      OHE. MATERIALS AND METHODS: This study was approved by the institutional ethics 
      committee, and informed consent was obtained. Resting-state functional magnetic 
      resonance (MR) data were compared between healthy controls and the following 
      groups of cirrhotic patients: (a) patients without MHE and without previous OHE, 
      (b) patients with current MHE and without previous OHE, and (c) patients with 
      previous OHE. Independent component analysis was applied to identify the best-fit 
      component for the default-mode network (DMN). One-way analysis of variance was 
      performed to detect different FC among groups. Pearson correlation analyses were 
      conducted to determine the relationships between FC and neurocognitive 
      performance. RESULTS: Two important regions within the DMN, including the 
      precuneus and posterior cingulate cortex and left medial frontal gyrus, showed 
      significantly different FC among the four groups. A trend of gradually reduced FC 
      in two regions was observed from controls, to patients without HE, and to 
      patients with current MHE, while patients with previous OHE showed remarkably 
      reduced FC in these two regions. Significant correlations were found between FC 
      and neurocognitive performance in cirrhotic patients. CONCLUSION: The reduced 
      resting-state FC within DMN was associated with neurocognitive impairments in MHE 
      and after clinical resolution of OHE. Previous OHE rather than current MHE might 
      be primarily related to brain dysfunction in patients with latent OHE. 
      SUPPLEMENTAL MATERIAL: 
      http://radiology.rsna.org/lookup/suppl/doi:10.1148/radiol.12120026/-/DC1.
CI  - RSNA, 2012
FAU - Chen, Hua-Jun
AU  - Chen HJ
AD  - Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of 
      Radiology, Zhongda Hospital, Medical School of Southeast University, 87 
      Dingjiaqiao Rd, Nanjing 210009, China.
FAU - Jiao, Yun
AU  - Jiao Y
FAU - Zhu, Xi-Qi
AU  - Zhu XQ
FAU - Zhang, Hong-Ying
AU  - Zhang HY
FAU - Liu, Jia-Cheng
AU  - Liu JC
FAU - Wen, Song
AU  - Wen S
FAU - Teng, Gao-Jun
AU  - Teng GJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121009
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
CIN - Radiology. 2013 Nov;269(2):622-3. PMID: 24155289
CIN - Radiology. 2013 Nov;269(2):623. PMID: 24312938
MH  - Brain/pathology/*physiopathology
MH  - Brain Mapping/*methods
MH  - Cognition Disorders/diagnosis/*etiology/*physiopathology
MH  - Female
MH  - Hepatic Encephalopathy/*complications/diagnosis/*physiopathology
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Severity of Illness Index
EDAT- 2012/10/11 06:00
MHDA- 2013/02/13 06:00
CRDT- 2012/10/11 06:00
PHST- 2012/10/11 06:00 [entrez]
PHST- 2012/10/11 06:00 [pubmed]
PHST- 2013/02/13 06:00 [medline]
AID - radiol.12120026 [pii]
AID - 10.1148/radiol.12120026 [doi]
PST - ppublish
SO  - Radiology. 2013 Jan;266(1):261-70. doi: 10.1148/radiol.12120026. Epub 2012 Oct 9.