PMID- 23048205
OWN - NLM
STAT- MEDLINE
DCOM- 20130425
LR  - 20221207
IS  - 1539-7262 (Electronic)
IS  - 0022-2275 (Print)
IS  - 0022-2275 (Linking)
VI  - 53
IP  - 12
DP  - 2012 Dec
TI  - Fatty acid and very low density lipoprotein metabolism in obese African American 
      and Caucasian women with type 2 diabetes.
PG  - 2767-72
LID - 10.1194/jlr.P030593 [doi]
AB  - Type 2 diabetes mellitus (T2DM) is associated with increased plasma triglyceride 
      (TG) concentrations, but African Americans (AA) have lower plasma TG than 
      Caucasians (CC). We evaluated the hypothesis that obese AA women have lower 
      plasma TG than obese CC women do because of differences in lipid kinetics. Eleven 
      AA and 11 CC obese women with T2DM, matched on body mass index (BMI) (AA = 37 +/- 
      1, CC = 37 +/- 1 kg/m(2)), age, duration of diabetes, percentage body fat, and 
      insulin sensitivity (S(I), determined by an intravenous glucose tolerance test), 
      were studied. Plasma TG concentration (AA = 1.14 +/- 0.11, CC = 1.88 +/- 0.18 
      mmol/l), FFA rate of appearance (R(a)) into plasma (AA = 419 +/- 27, CC = 503 +/- 31 
      micromol.min(-1)), and total VLDL-TG secretion rate (AA = 18 +/- 2, CC = 29 +/- 4 
      micromol.min(-1)) were lower in AA than CC women (all P < 0.05). In contrast, plasma 
      total apolipoprotein (apo)B-100 concentration (AA = 1,542 +/- 179, CC = 1,620 +/- 118 
      nmol/l) and VLDL-apoB-100 secretion rate (AA = 1.3 +/- 0.1, CC = 1.3 +/- 0.1 
      nmol.min(-1)) were similar in both groups, so the molar ratio of VLDL-TG 
      secretion rate to VLDL-apoB-100 secretion rate was lower in AA women than in CC 
      women. VLDL-TG concentration was lower in AA women due to lower total VLDL-TG 
      secretion rate. However, the VLDL-apoB-100 secretion rate was the same in both 
      groups, demonstrating that AA women secrete smaller VLDL particles containing 
      less TG than do CC women.
FAU - Miller, Bernard V 3rd
AU  - Miller BV 3rd
AD  - Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine, 
      Washington University School of Medicine, Saint Louis, MO 63110, USA.
FAU - Patterson, Bruce W
AU  - Patterson BW
FAU - Okunade, Adewole
AU  - Okunade A
FAU - Klein, Samuel
AU  - Klein S
LA  - eng
GR  - P30 DK056341/DK/NIDDK NIH HHS/United States
GR  - UL1 RR024992/RR/NCRR NIH HHS/United States
GR  - DK-37948/DK/NIDDK NIH HHS/United States
GR  - UL1 TR000448/TR/NCATS NIH HHS/United States
GR  - P41 RR000954/RR/NCRR NIH HHS/United States
GR  - RR-024992/RR/NCRR NIH HHS/United States
GR  - RR-00954/RR/NCRR NIH HHS/United States
GR  - P30 DK020579/DK/NIDDK NIH HHS/United States
GR  - R01 DK037948/DK/NIDDK NIH HHS/United States
GR  - DK-56341/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20121009
PL  - United States
TA  - J Lipid Res
JT  - Journal of lipid research
JID - 0376606
RN  - 0 (Fatty Acids)
RN  - 0 (Lipoproteins, LDL)
SB  - IM
MH  - *Black or African American
MH  - Diabetes Mellitus, Type 2/blood/epidemiology/*metabolism
MH  - Fatty Acids/blood/*metabolism
MH  - Female
MH  - Humans
MH  - Kinetics
MH  - Lipoproteins, LDL/blood/*metabolism
MH  - Middle Aged
MH  - Obesity/blood/epidemiology/*metabolism
MH  - *White People
PMC - PMC3494253
EDAT- 2012/10/11 06:00
MHDA- 2013/04/26 06:00
PMCR- 2013/12/01
CRDT- 2012/10/11 06:00
PHST- 2012/10/11 06:00 [entrez]
PHST- 2012/10/11 06:00 [pubmed]
PHST- 2013/04/26 06:00 [medline]
PHST- 2013/12/01 00:00 [pmc-release]
AID - S0022-2275(20)41811-5 [pii]
AID - p030593 [pii]
AID - 10.1194/jlr.P030593 [doi]
PST - ppublish
SO  - J Lipid Res. 2012 Dec;53(12):2767-72. doi: 10.1194/jlr.P030593. Epub 2012 Oct 9.