PMID- 23049265
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121011
LR  - 20211021
IS  - 1178-7074 (Electronic)
IS  - 1178-7074 (Linking)
VI  - 5
DP  - 2012
TI  - Efficacy and safety of delapril/indapamide compared to different 
      ACE-inhibitor/hydrochlorothiazide combinations: a meta-analysis.
PG  - 725-34
LID - 10.2147/IJGM.S35220 [doi]
AB  - The main objective of this meta-analysis was to compare the efficacy of the 
      combination of delapril and indapamide (D+I) to different angiotensin-converting 
      enzyme inhibitor (ACEi) plus hydrochlorothiazide (HCTZ) combinations for the 
      treatment of mild-to-moderate hypertension. A secondary objective was to examine 
      the safety of these two combinations. Studies comparing the efficacy of D+I to 
      ACEi+HCTZ combinations in hypertensive patients and published on computerized 
      databases (1974-2010) were considered. Endpoints included percentage of 
      normalized patients, of responders, change in diastolic and systolic blood 
      pressure (DBP/SBP) at different time-points, percentage of adverse events (AEs), 
      and percentage of withdrawal. Four head-to-head randomized controlled trials 
      (D+I-treated, n = 643; ACEi+HCTZ-treated, n = 629) were included. Meta-analysis 
      indicated that D+I-treated patients had a higher proportion with normalized blood 
      pressure (P = 0.024) or responders (P = 0.002) compared to ACEi+HCTZ-treated 
      patients. No difference was observed between treatments on absolute values of DBP 
      and SBP at different time-points. Although the rate of patients reporting at 
      least one AE was similar in both groups (10.4% versus 9.9%), events leading to 
      study withdrawal were lower in the D+I group versus the ACEi+HCTZ group (2.3% 
      versus 4.8%, respectively; P = 0.018). This meta-analysis suggests that treatment 
      with D+I could provide a higher proportion of normalized or responder patients 
      with good tolerability compared to ACEi+HCTZ combinations.
FAU - Circelli, Maria
AU  - Circelli M
AD  - Chiesi Farmaceutici, Direzione Medica, Parma, Italy.
FAU - Nicolini, Gabriele
AU  - Nicolini G
FAU - Egan, Colin G
AU  - Egan CG
FAU - Cremonesi, Giovanni
AU  - Cremonesi G
LA  - eng
PT  - Journal Article
DEP - 20120829
PL  - New Zealand
TA  - Int J Gen Med
JT  - International journal of general medicine
JID - 101515487
PMC - PMC3459665
OTO - NOTNLM
OT  - ACE inhibitor
OT  - delapril
OT  - diuretic
OT  - hypertension
OT  - indapamide
OT  - meta-analysis
EDAT- 2012/10/11 06:00
MHDA- 2012/10/11 06:01
PMCR- 2012/08/29
CRDT- 2012/10/11 06:00
PHST- 2012/10/11 06:00 [entrez]
PHST- 2012/10/11 06:00 [pubmed]
PHST- 2012/10/11 06:01 [medline]
PHST- 2012/08/29 00:00 [pmc-release]
AID - ijgm-5-725 [pii]
AID - 10.2147/IJGM.S35220 [doi]
PST - ppublish
SO  - Int J Gen Med. 2012;5:725-34. doi: 10.2147/IJGM.S35220. Epub 2012 Aug 29.