PMID- 23049380
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121011
LR  - 20211021
IS  - 1806-0870 (Electronic)
IS  - 1516-8484 (Print)
IS  - 1516-8484 (Linking)
VI  - 34
IP  - 1
DP  - 2012
TI  - HLA-A, B and DRB1 allele and haplotype frequencies in volunteer bone marrow 
      donors from the north of Parana State.
PG  - 25-30
LID - 10.5581/1516-8484.20120010 [doi]
AB  - BACKGROUND: Knowledge of allele and haplotype frequencies of the human leukocyte 
      antigen (HLA) system is important in the search for unrelated bone marrow donors. 
      The Brazilian population is very heterogeneous and the HLA system is highly 
      informative of populations because of the high level of polymorphisms. AIM: The 
      aim of this study was to characterize the immunogenetic profile of ethnic groups 
      (Caucasians, Afro-Brazilians and Asians) in the north of Parana State. METHODS: A 
      study was carried out of 3978 voluntary bone marrow donors registered in the 
      Brazilian National Bone Marrow Donor Registry and typed for the HLA-A, B and DRB1 
      (low resolution) loci. The alleles were characterized by the polymerase chain 
      reaction sequence-specific oligonucleotides method using the LabType SSO kit (One 
      Lambda, CA, USA). The ARLEQUIN v.3.11 computer program was used to calculate 
      allele and haplotype frequencies RESULTS: The most common alleles found in 
      Caucasians were HLA-A*02, 24, 01; HLA-B*35, 44, 51; DRB1*11, 13, 07; for 
      Afro-Brazilians they were HLA-A*02, 03, 30; HLA-B*35, 15, 44; DRB1*13, 11, 03; 
      and for Asians they were: HLA-A*24, 02, 26; HLA-B*40, 51, 52; DRB1*04, 15, 09. 
      The most common haplotype combinations were: HLA-A*01, B*08, DRB1*03 and 
      HLA-A*29, B*44, DRB1*07 for Caucasians; HLA-A*29, B*44, DRB1*07 and HLA-A*01, 
      B*08 and DRB1*03 for Afro-Brazilians; and HLA-A*24, B*52, DRB1*15 and HLA-A*24, 
      B*40 and DRB1*09 for Asians. CONCLUSION: There is a need to target and expand 
      bone marrow donor campaigns in the north of Parana State. The data of this study 
      may be used as a reference by the Instituto Nacional de Cancer/Brazilian National 
      Bone Marrow Donor Registry to evaluate the immunogenetic profile of populations 
      in specific regions and in the selection of bone marrow donors.
FAU - Bardi, Marlene Silva
AU  - Bardi MS
AD  - Laboratory of Histocompatibility, Hospital Universitario, Universidade Estadual 
      de Londrina - UEL, Londrina, PR, Brazil.
FAU - Jarduli, Luciana Ribeiro
AU  - Jarduli LR
FAU - Jorge, Adylson Justino
AU  - Jorge AJ
FAU - Camargo, Rossana Batista Oliveira Godoy
AU  - Camargo RB
FAU - Carneiro, Fernando Pagotto
AU  - Carneiro FP
FAU - Gelinski, Jair Roberto
AU  - Gelinski JR
FAU - Silva, Roseclei Assuncao Feliciano
AU  - Silva RA
FAU - Lavado, Edson Lopes
AU  - Lavado EL
LA  - eng
PT  - Journal Article
PL  - Brazil
TA  - Rev Bras Hematol Hemoter
JT  - Revista brasileira de hematologia e hemoterapia
JID - 101220159
PMC - PMC3459602
OTO - NOTNLM
OT  - Gene frequency
OT  - Genetic polymorphism
OT  - HLA antigens
OT  - Transplantation
COIS- Conflict-of-interest disclosure: The authors declare no competing financial 
      interest
EDAT- 2012/10/11 06:00
MHDA- 2012/10/11 06:01
PMCR- 2012/01/01
CRDT- 2012/10/11 06:00
PHST- 2010/11/12 00:00 [received]
PHST- 2011/11/29 00:00 [accepted]
PHST- 2012/10/11 06:00 [entrez]
PHST- 2012/10/11 06:00 [pubmed]
PHST- 2012/10/11 06:01 [medline]
PHST- 2012/01/01 00:00 [pmc-release]
AID - 10.5581/1516-8484.20120010 [doi]
PST - ppublish
SO  - Rev Bras Hematol Hemoter. 2012;34(1):25-30. doi: 10.5581/1516-8484.20120010.